6087-13-4 | 2-Fluoropropionic acid

CAS:6087-13-4 | 2-Fluoropropionic acid ,Description

2-Fluoropropionic acid, also known as 2-fluoroacetic acid, is a naturally occurring organic compound with the molecular formula C3H4O2F. It is a colorless, odorless, and non-toxic solid that is highly soluble in water. 2-Fluoropropionic acid has a wide range of applications in both industrial and scientific research. It is used in the synthesis of a variety of organic compounds, such as pharmaceuticals, pesticides, and dyes. In addition, 2-fluoropropionic acid has been studied for its potential use in medical applications, such as cancer treatment and gene therapy.
 

Scientific Research Applications

Synthesis and Evaluation for Medical Applications

• Synthesis of Optically Active Analogs: 2-Fluoropropionic acid has been utilized in the synthesis of optically active 2-aryl-2-fluoropropionic acids, which are analogs of non-steroidal anti-inflammatory drugs (NSAIDs). These compounds serve as non-epimerizable mimics of 2-arylpropionic acids, highlighting the potential of 2-fluoropropionic acid in medicinal chemistry (Fujisawa et al., 2005).

Use in Diagnostic Imaging

• Radiolabeling for PET Imaging: 2-Fluoropropionic acid has been applied as a prosthetic group for radiolabeling proteins and peptides in positron emission tomography (PET) imaging. This application is significant in targeted imaging for diagnostic purposes, particularly in oncology (Mařı́k et al., 2006) .
• Breast Cancer Imaging: Research has indicated the efficacy of 2-Fluoropropionic acid in imaging breast cancer in mice models. It demonstrates potential for clinical application in noninvasive imaging of breast cancer (Dang et al., 2015).

Biocatalytic Synthesis

• Environmental and Safety Benefits: The biocatalytic synthesis of 2-fluoro-3-hydroxypropionic acid, a derivative of 2-fluoropropionic acid, offers considerable advantages in terms of environmental and safety impacts. This approach uses E. coli for the synthesis and has applications in the creation of other fluorides, highlighting the role of 2-fluoropropionic acid in sustainable chemistry (Liu et al., 2022).

Analytical Chemistry and Synthesis Techniques

• Microwave Synthesis: The microwave catalytic synthesis method has been employed for the production of 2-fluoropropionic acid, demonstrating an improvement in yield and process efficiency. This showcases the compound's role in advancing synthetic methodologies (杨博文 et al., 2017) .

Enzymatic Studies

• Enzymatic Hydrolysis Research: 2-Fluoropropionic acid has been a subject in the study of enzymatic hydrolysis, offering insights into biochemical processes and enzyme mechanisms. This research is vital for understanding the interaction of enzymes with fluorinated compounds (Bellezza et al., 2005).

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