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Purchase CAS:625120-14-1 | 5-(trifluoromethyl)-3-Isoxazolecarboxylic acid,view related peer-reviewed papers,technical documents,similar products,MSDS & more.The compound “5-(Trifluoromethyl)-1,2-oxazole-3-carboxylic acid” likely belongs to the class of organic compounds known as oxazoles, which are aromatic compounds containing an oxazole ring . Trifluoromethyl groups are often used in pharmaceuticals and agrochemicals due to their unique physicochemi...
The compound “5-(Trifluoromethyl)-1,2-oxazole-3-carboxylic acid” likely belongs to the class of organic compounds known as oxazoles, which are aromatic compounds containing an oxazole ring. Trifluoromethyl groups are often used in pharmaceuticals and agrochemicals due to their unique physicochemical properties.
While specific synthesis methods for “5-(Trifluoromethyl)-1,2-oxazole-3-carboxylic acid” were not found, trifluoromethyl-containing compounds are often synthesized using various methods. For instance, trifluoromethylpyridines, which are structurally similar, are synthesized via lithiation and reaction with electrophiles.
The molecular structure of “5-(Trifluoromethyl)-1,2-oxazole-3-carboxylic acid” would likely include an oxazole ring with a trifluoromethyl group attached at the 5-position and a carboxylic acid group at the 3-position.
1,2,3-Triazoles have been extensively studied for their broad spectrum of biological activities and diverse applications in drug discovery, material science, and synthetic chemistry. The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), known as a click reaction, is highlighted for its efficiency in synthesizing 1,4-disubstituted 1,2,3-triazoles. This methodology offers high selectivity, wide scope, and yields, making it a powerful tool for constructing complex molecules from simple substrates. Such synthetic versatility underscores the importance of triazoles in developing new therapeutic agents and materials (Kaushik et al., 2019).
The synthesis of 1,2,3-triazoles using eco-friendly procedures has been a focus of recent research. Various novel and easily recoverable catalysts, such as rhizobial cyclic β-1,2 glucan and water extract of banana, have been employed to enhance the eco-friendliness of the CuAAC reaction. These methodologies not only offer advantages like shorter reaction times and higher yields but also align with green chemistry principles by reducing environmental impact. The application of these procedures extends beyond drug synthesis, offering potential benefits in industrial processes and other areas (de Souza et al., 2019).
Studies on the microbial degradation of polyfluoroalkyl chemicals highlight the environmental fate of these persistent compounds. The degradation of non-fluorinated functionalities in polyfluoroalkyl and perfluoroalkyl chemicals can lead to the formation of perfluoroalkyl carboxylic and sulfonic acids, such as PFOA and PFOS. Understanding the biodegradability of these compounds is crucial for assessing their environmental impact and for the development of strategies to mitigate their persistence (Liu & Avendaño, 2013).
The transition to fluorinated alternatives to long-chain perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkane sulfonic acids (PFSAs) has been ongoing since 2000. Despite their widespread use in various applications, the environmental releases, persistence, and human and biota exposure levels of these alternatives are not well understood. This knowledge gap hampers the risk assessment and management of these chemicals, underscoring the need for further research to ensure their safety for human health and the environment (Wang et al., 2013).
Trifluoromethylpyrazoles have garnered attention for their potential as anti-inflammatory and antibacterial agents. The presence of a trifluoromethyl group, especially at the 3- or 5-position on the pyrazole nucleus, significantly influences the activity profile of these compounds. This review highlights the importance of trifluoromethylpyrazoles in medicinal chemistry, encouraging further exploration to discover novel agents with enhanced efficacy and reduced side effects (Kaur et al., 2015).
While specific future directions for “5-(Trifluoromethyl)-1,2-oxazole-3-carboxylic acid” were not found, research into trifluoromethyl-containing compounds is ongoing, with potential applications in pharmaceuticals, agrochemicals, and functional materials.
Product Name: | 5-(trifluoromethyl)-3-Isoxazolecarboxylic acid |
Synonyms: | 5-(trifluoromethyl)-3-Isoxazolecarboxylic acid;5-(trifluoromethyl)isoxazole-3-carboxylic acid;5-(trifluoromethyl)-1,2-oxazole-3-carboxylic acid;3-Isoxazolecarboxylic acid, 5-(trifluoromethyl)-;5-(trifluoromethyl)-1,2-oxazol-3-carboxylic? acid |
CAS: | 625120-14-1 |
MF: | C5H2F3NO3 |
MW: | 181.07 |
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Mol File: | 625120-14-1.mol |
5-(trifluoromethyl)-3-Isoxazolecarboxylic acid Chemical Properties |