63517-29-3 | XtalFluor-E

CAS:63517-29-3 | XtalFluor-E ,Description

XtalFluor-E is a fluorescent dye that is used in a variety of scientific research applications. It is a highly versatile dye that is used to label proteins, nucleic acids, and other molecules for a variety of imaging and detection techniques. XtalFluor-E is a member of the XtalFluor family of fluorescent dyes, which are widely used in biomedical research. 
 

Scientific Research Applications

1. Versatile Reagent in Organic TransformationsXtalFluor-E is widely recognized for its versatility in organic synthesis. It is primarily known for the deoxyfluorination of carbonyl compounds and alcohols. Besides its primary use, XtalFluor-E has been extensively employed in various chemical transformations like dehydration, cyclodehydration, ring expansion, formylation, and proto-functionalization (Mohammadkhani & Heravi, 2019).

2. Enhanced Thermal Stability and Ease of HandlingXtalFluor-E demonstrates superior stability and ease of handling compared to other fluorinating agents. Its stability and non-corrosive nature allow for use in standard borosilicate vessels. It is effective in converting alcohols to alkyl fluorides and carbonyls to gem-difluorides, often exhibiting more selectivity and yielding fewer elimination side products than other reagents (L’Heureux et al., 2010) .

3. Proto-Functionalization of N-Vinyl AmidesXtalFluor-E has been used in catalytic proto-functionalization of activated olefins. This application involves proto etherification of enamides to produce N,O-acetals with high yields (Yi et al., 2017) .

4. Alternative to POCl3 in Vilsmeier-Haack FormylationIt serves as an alternative to POCl3 in the Vilsmeier-Haack formylation of C-2-glycals, enabling the synthesis of C-2-formylated disaccharide glycal (Roudias et al., 2018).

5. Synthesis of Acyl Fluorides from Carboxylic AcidsXtalFluor-E has been used for synthesizing acyl fluorides from carboxylic acids, demonstrating a broad range of applications and high yields (Gonay et al., 2020).

6. Formation of Isocyanides through Dehydration of FormamidesThe formation of isocyanides from formamides using XtalFluor-E is another notable application, producing isocyanides in high yields and purity (Keita et al., 2015).

7. Synthesis of 2-Oxazolines and Related HeterocyclesXtalFluor-E is utilized as a cyclodehydration agent for preparing 2-oxazolines and related N-containing heterocycles under mild conditions (Pouliot et al., 2012).

8. In Situ Activation of Benzyl AlcoholsThe reagent is used for in situ activation of benzyl alcohols, leading to the formation of diarylmethanes and triarylmethanes without the need for transition metals or strong Lewis acids (Desroches et al., 2015).

9. Esterification of Carboxylic Acids with Perfluorinated AlcoholsIt mediates the direct esterification of carboxylic acids with perfluorinated alcohols, broadening its applicability in synthesizing polyfluorinated esters (Vandamme et al., 2016).

10. Amidation of Carboxylic AcidsXtalFluor-E is effective as an activating agent in the amidation of carboxylic acids, capable of transforming even less reactive acids to amides (Orliac et al., 2013).

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