64372-62-9 | 2-Chloro-5-(trifluoromethyl)benzyl alcohol

CAS:64372-62-9 | 2-Chloro-5-(trifluoromethyl)benzyl alcohol ,Description

2-Chloro-5-(trifluoromethyl)benzyl alcohol, also known as 2-CFTB, is a chemical compound found in a variety of products including pharmaceuticals, food additives, and cosmetics. It is a colorless, odourless liquid with a density of 1.25 g/cm3 and a boiling point of 105°C. 2-CFTB is used in several different applications, including as a solvent, a stabilizer, and a surfactant. It is also used in the synthesis of other compounds.
 

Scientific Research Applications

Benzylation of Alcohols

2-Chloro-5-(trifluoromethyl)benzyl alcohol is utilized in the benzylation of alcohols. This process is fundamental in organic synthesis for protecting alcohol functionalities and modifying molecular structures. For example, Poon and Dudley (2006) describe a method for converting alcohols into benzyl ethers using a stable organic salt, showcasing the potential of benzyl alcohols in synthetic chemistry (Poon & Dudley, 2006).

Photocatalytic Oxidation

The photocatalytic oxidation of benzyl alcohol and its derivatives, including 2-Chloro-5-(trifluoromethyl)benzyl alcohol, has been studied for the conversion into corresponding aldehydes. Higashimoto et al. (2009) found that this reaction proceeds with high conversion and selectivity under an O2 atmosphere, highlighting the role of benzyl alcohols in photocatalytic processes (Higashimoto et al., 2009).

Chemical Synthesis and Reactions

2-Chloro-5-(trifluoromethyl)benzyl alcohol is involved in various chemical synthesis and reactions. For instance, Sun et al. (2008) developed a method for the selective chlorination of benzyl alcohols under neutral conditions, which is a critical reaction in organic and medicinal chemistry (Sun et al., 2008). Additionally, Carter et al. (1958) investigated the antibacterial and antifungal properties of substituted benzyl alcohols, providing insights into the biomedical applications of these compounds (Carter et al., 1958).

Application in Organic Synthesis

The role of benzyl alcohols in organic synthesis is further exemplified by Yamada, Fujita, and Kunishima (2012), who introduced a novel acid-catalyzed O-benzylating reagent with high atom economy, demonstrating the versatility of benzyl alcohols in synthetic applications (Yamada, Fujita, & Kunishima, 2012).

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