65094-22-6 | Bromodifluoromethyl diethylphosphonate

CAS:65094-22-6 | Bromodifluoromethyl diethylphosphonate ,Description

Bromodifluoromethyl diethylphosphonate (BDMDE) is an organophosphonate compound that has a wide range of applications in scientific research. It is used as a reagent in organic synthesis, as a catalyst for biochemical reactions, and as a tool to study the structure and function of biological molecules. 
 

Scientific Research Applications

• Photoredox-Catalyzed Bromodifluoromethylation of Alkenes: Under photoredox conditions, difluoromethyltriphenylphosphonium bromide, a precursor of the CF2H radical, is used for bromodifluoromethylation of alkenes, resulting in the selective formation of bromodifluoromethylated products (Lin, Ran, Xu, & Qing, 2016).
• Synthesis of α-Monohalogenated Diethyl Benzylphosphonates: Starting from diethyl benzylphosphonates, a variety of α-monohalogenated diethyl benzylphosphonates are obtained using a high yielding one-pot procedure (Iorga, Eymery, & Savignac, 1999).
• C-H Difluoromethylenephosphonation of Arenes and Heteroarenes: This process involves a room-temperature protocol for the C-H difluoromethylenephosphonation of arenes and heteroarenes, using diethyl bromodifluoromethyl phosphonate as a difluoromethyl radical precursor (Wang et al., 2014).
• Preparation of Diethyl 2-Oxo-1,1-Difluorophosphonates: Diethyl(bromodifluoromethyl)phosphonate reacts with activated zinc, leading to various acylated products which are useful in organic synthesis (Tsai, 1997).
• Difluoromethylation of Phenols and Thiophenols: Diethyl bromodifluoromethylphosphonate, as a difluorocarbene precursor, is used for the difluoromethylation of phenols and thiophenols. This method has environmentally friendly by-products and is effective under mild conditions (Zafrani, Sod-Moriah, & Segall, 2009).
• Synthesis of Various Fluoromethylene Phosphonium Ylides: This involves reactions with a variety of electrophiles, serving as a source for the introduction of the difluoromethylene phosphonate group into organic compounds (Burton, Takei, & Shin-Ya, 1981).

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