652-03-9 | 3,4,5,6-Tetrafluorophthalic acid

CAS:652-03-9 | 3,4,5,6-Tetrafluorophthalic acid ,Description

3,4,5,6-Tetrafluorophthalic acid (TFP) is an organic compound with the chemical formula C8H2F4O4. It is a colorless solid that is soluble in water and organic solvents. It is used in a variety of applications, including as a reagent for the synthesis of organic compounds, as a catalyst for the polymerization of vinyl monomers, and as an intermediate in the synthesis of pharmaceuticals, among other uses. TFP is also known as 2,3,4,5-tetrafluoro-1-phthalic acid, 2,3,4,5-tetrafluorophthalic acid, and 2,3,4,5-tetrafluorophthalic anhydride.
 

Scientific Research Applications

Synthesis of Pharmaceuticals

3,4,5,6-Tetrafluorophthalic acid is employed in the synthesis of pharmaceutical compounds. For example, it is used in the process improvement for synthesizing Gatifloxacin, an antibiotic. The synthesis involves steps like hydrolysis, decarboxylation, and methylation, among others, and is adaptable for industrial scale-up (Sun You-guang, 2009).

Green Technology in Pharmaceutical Intermediates

A green technology method utilizes 3,4,5,6-tetrafluorophthalic acid for decarboxylation to produce 2,3,4,5-tetrafluorobenzoic acid, an important pharmaceutical intermediate. This process achieves a high conversion rate and selectivity under certain conditions, demonstrating its efficiency and environmental friendliness (Jie Fu, J. Mo, Jing Zhang, Xiuyang Lu, 2016).

Development of Polyimides

The compound plays a critical role in the development of polyimides. Aminodefluorination of tetrafluorophthalic acid results in high-yield production of derivatives useful for synthesizing perfluoroaromatic AB-type polyimides. These polyimides show promise in optical communication systems due to their unique absorption properties (T. Vaganova, I. Shundrina, S. Z. Kusov, E. Karpova, I. Bagryanskaya, E. Malykhin, 2012).

Luminescent Properties in Coordination Polymers

3,4,5,6-Tetrafluorophthalic acid is used in synthesizing europium-based coordination polymers with luminescent properties. These polymers have potential applications in advanced luminescent materials and devices (Weimin Chen, Sha‐Sha Li, C. Zeng, Shengliang Zhong, 2017).

More Information