653-37-2 | Pentafluorobenzaldehyde

CAS:653-37-2 | Pentafluorobenzaldehyde ,Description

Pentafluorobenzaldehyde (PFBA) is an organic compound with the molecular formula C6F5CHO. It is a colorless liquid and is miscible with most organic solvents. PFBA has a variety of applications in scientific research and lab experiments due to its unique properties. 
 

Scientific Research Applications

• Organic Synthesis: Pentafluorobenzaldehyde is used in various organic synthesis processes. It can undergo nucleophilic substitutions, nucleophilic additions, haloform reactions, and cyclization reactions (Pažitný, Solčan, & Végh, 2009) .
• Synthesis of Corrole and Oligopyrromethenes: When combined with pyrrole in a solvent-free environment, pentafluorobenzaldehyde leads to the synthesis of corrole and oligopyrromethenes (Gross et al., 1999).
• Derivative Formation: It can be converted into a variety of derivatives, such as pentafluorostilbene, pentafluorocinnamic acid, azine, oxime, and various acetals. Other derivatives are made by replacing fluorine with other elements (Aroskar et al., 1968).
• Synthesis of Conjugated Macrocycles: Acid-catalyzed condensation of furan and pentafluorobenzaldehyde results in conjugated macrocycles with furan rings, similar to annulenes (Reddy, Mandal, & Anand, 2006).
• Chemical Reactions Involving Aldehyde Group: Pentafluorobenzaldehyde interacts with various compounds to form derivatives like pentafluorobenzylidene chloride (Petrova, Platonov, & Pokrovskii, 2002).
• Analytical Chemistry: It is used in dispersive liquid-liquid microextraction and gas chromatography-mass spectrometric detection for determining anilines in river water (Chiang & Huang, 2008) .
• Synthesis of Fluorinated Analogs of Pharmaceuticals: Asymmetric “allyl”boration of pentafluorobenzaldehyde has been used in the synthesis of pentafluorophenyl analog of key pharmacophore of statin drugs (Ramachandran et al., 2004) .
• NMR Spectroscopy Studies: The spin–spin coupling constants between the aldehydic proton and the fluorine nuclei in pentafluorobenzaldehyde have been a subject of study in NMR spectroscopy (Schaefer & Marat, 1981) .
• Synthesis of Aromatic Polymers: Pentafluorobenzaldehyde is used in the synthesis of novel aromatic polymers with pentafluorophenyl pendent groups (Velasco et al., 2008).

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