683-98-7 | Methyl Bromodifluoroacetate

CAS:683-98-7 | Methyl Bromodifluoroacetate ,Description

Methyl bromodifluoroacetate (MBDFA) is a highly reactive, organofluorine compound with a wide range of applications in the chemical and biological sciences. It is a colorless liquid that is widely used as a reagent for the synthesis of organic compounds and for the study of biochemical and physiological processes. MBDFA has been used in a variety of laboratory experiments and has been found to be useful for its ability to rapidly react with a variety of molecules.
 

Scientific Research Applications

• Copper-Catalyzed N-Formylation of AminesMethyl Bromodifluoroacetate is used in the N-formylation of amines. This process involves copper-catalyzed reactions and yields N-formamides from primary, secondary, cyclic arylamines, and aliphatic amines (Xiao-fang Li et al., 2018).
• Bromodifluoroacetic Acid Synthesis TechnologyIt plays a role in bromodifluoroacetic acid synthesis through transesterification reactions. The process involves reacting methyl and ethyl esters of bromodifluoroacetic acid with trifluoroacetic acid, using sulfuric acid as a catalyst (E. V. Lupachev et al., 2019).
• Enantioselective Reformatsky ReactionMethyl Bromodifluoroacetate is utilized in the enantioselective Reformatsky reaction. This involves adding the Reformatsky reagent generated from methyl bromodifluoroacetate to benzaldehyde in the presence of specific reagents, producing highly enantioselective adducts (M. Braun et al., 1995).
• Radical Reactions for Synthesis of Organic CompoundsIt is used in radical reactions with vinyl ethers for synthesizing difluoroacetyl-substituted acetals. This methodology aids in the synthesis of complex organic compounds like 3,3-Difluoro-GABA (I. Kondratov et al., 2015).
• Organocopper Reagent Derived ReactionsReactions of methyl bromodifluoroacetate in the presence of organocopper reagents have been explored for the synthesis of compounds containing CF2 groups. These reactions provide novel routes for synthesizing various organic compounds (Kazuyuki Sato et al., 2002).
• Synthesis of Difluoromethylated ArenesMethyl Bromodifluoroacetate is used in the Pd-catalyzed difluoromethylation of aryl boronic acids. This process is notable for its high efficiency and compatibility with various functional groups, proving useful in drug discovery and development (Zhange Feng et al., 2016).

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