684-07-1 | 3,3,3-Trifluoro-2-hydroxypropanoic acid

CAS:684-07-1 | 3,3,3-Trifluoro-2-hydroxypropanoic acid ,Description

3,3,3-Trifluoro-2-hydroxypropanoic acid (TFHPA) is a versatile chemical compound with a wide range of applications in the scientific research field. It is a carboxylic acid with a trifluoromethyl group attached to the alpha carbon, and is also known as trifluoromethyl propionic acid or trifluoropropionic acid. It is a colorless liquid that is insoluble in water but soluble in many organic solvents. TFHPA has been used as a catalyst in organic synthesis, as a reagent for the synthesis of other compounds, and for multiple biochemical and physiological processes. 
 

Scientific Research Applications

• Crystallography and Molecular Structure: 3,3,3-Trifluoro-2-hydroxypropanoic acid has been characterized through crystallography, revealing insights into its molecular structure and intermolecular interactions (Gerber & Betz, 2013).
• Enantioselective Hydrolysis: Microorganisms capable of enantioselectively hydrolyzing derivatives of this compound have been isolated, allowing the preparation of its enantiomers for potential pharmaceutical applications (Fuhshuku et al., 2014).
• Industrial Production and Bioplastic Potential: It is a precursor in the production of chemicals like acrylic acid and its derivatives. In polymerized form, it can be used in bioplastic production, with advances in metabolic engineering and synthetic biology enhancing its bio-production (Jers et al., 2019).
• Catalytic Chemical Methods: Eco-sustainable processes leading to the production of 3,3,3-Trifluoro-2-hydroxypropanoic acid have been explored, highlighting the potential of catalytic chemical methods in green chemistry (Pina et al., 2011).
• Biotransformation in Animals: Studies on rabbits have shown that 2,3,3,3-tetrafluoropropene, a related compound, is metabolized to form derivatives including N-acetyl-S-(3,3,3-trifluoro-2-hydroxypropanyl)-l-cysteine, with implications for toxicity and pharmacokinetics (Schuster et al., 2010).
• Bacterial Enzyme for Synthesis: A novel amidase from Burkholderia phytofirmans has been characterized for the synthesis of enantiomerically pure derivatives of this acid, highlighting its potential in pharmaceutical synthesis (Wu et al., 2017).
• Oxidation of Levulinic Acid: It can be produced by oxidizing biomass-derived levulinic acid, demonstrating a sustainable approach to its synthesis (Wu et al., 2015).
• Chiral Derivatizing Agent: Mosher’s Acid, a derivative, can serve as a chiral derivatizing agent, useful in analytical chemistry (Savich & Tanski, 2020).
• Bioconversion in Bacillus subtilis: Genetically engineered Bacillus subtilis has been investigated for converting glycerol into 3-hydroxypropanoic acid, an important platform chemical (Kalantari et al., 2017).

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