685-88-1 | Diethyl fluoromalonate

CAS:685-88-1 | Diethyl fluoromalonate ,Description

Diethyl fluoromalonate (DEF) is an organic compound with the chemical formula C6H10O4F2. It is used as a reagent in organic synthesis and is a key intermediate in the synthesis of many pharmaceuticals. DEF is also used in a variety of laboratory experiments, including studies of biochemical and physiological effects. 
 

Scientific Research Applications

Diethyl fluoromalonate has a wide range of applications in scientific research. It is commonly used as a reagent in organic synthesis, and is a key intermediate in the synthesis of many pharmaceuticals. Diethyl fluoromalonate is also used in a variety of laboratory experiments, including studies of biochemical and physiological effects. It has been shown to have anti-inflammatory and analgesic effects in animal models, and is being studied for potential use in treating chronic pain. In addition, Diethyl fluoromalonate has been used in studies of enzyme inhibition, protein expression, and drug metabolism.
 

Mechanism of Action

The mechanism of action of Diethyl fluoromalonate is not fully understood. It is believed to act as a reversible inhibitor of the enzyme acetylcholinesterase, which is involved in the breakdown of the neurotransmitter acetylcholine. This inhibition of acetylcholinesterase results in an increase of acetylcholine levels in the body, which has been shown to have anti-inflammatory and analgesic effects.
 

Biochemical and Physiological Effects

Diethyl fluoromalonate has been shown to have anti-inflammatory and analgesic effects in animal models. It has also been shown to have an inhibitory effect on the enzyme acetylcholinesterase, which is involved in the breakdown of the neurotransmitter acetylcholine. In addition, Diethyl fluoromalonate has been shown to have an inhibitory effect on the enzyme cyclooxygenase, which is involved in the synthesis of prostaglandins. These prostaglandins are involved in inflammation and pain pathways.
 

Advantages and Limitations for Lab Experiments

Diethyl fluoromalonate is a useful reagent for laboratory experiments due to its low cost and easy availability. It is also relatively stable, with a shelf life of up to two years. However, Diethyl fluoromalonate is a highly toxic compound and should be handled with care. In addition, it is not water soluble and must be dissolved in an appropriate solvent prior to use.
 

Future Directions

Potential future directions for research using Diethyl fluoromalonate include further studies of its anti-inflammatory and analgesic effects, as well as its potential use in treating chronic pain. In addition, further studies of its inhibitory effects on enzymes, such as acetylcholinesterase and cyclooxygenase, could provide insight into the mechanism of action of Diethyl fluoromalonate and its potential therapeutic uses. Finally, further studies of its structure-activity relationships could provide insight into the design of novel compounds with improved pharmacological properties.

More Information