702641-04-1 | 2-Iodo-5-(trifluoromethyl)benzoic acid

CAS:702641-04-1 | 2-Iodo-5-(trifluoromethyl)benzoic acid,Description

Synthesis Analysis

The synthesis of 2-Iodo-5-(trifluoromethyl)benzoic acid and related compounds involves complex chemical reactions, often employing iodine reagents and specific reaction conditions. For example, Yusubov et al. (2008) described the use of iodine(III) reagents derived from 3-iodosylbenzoic acid in the synthesis of related compounds, demonstrating the importance of specific iodine-based reagents in these syntheses (Yusubov et al., 2008).

Molecular Structure Analysis

The molecular structure of this compound and its derivatives can be characterized by various techniques such as X-ray crystallography. Nemykin et al. (2011) investigated the structural aspects of benziodoxaborole derivatives, highlighting the planar geometry and short endocyclic I-O bond distances, which are indicative of the molecular structure of such compounds (Nemykin et al., 2011).

Chemical Reactions and Properties

Compounds like 2-Iodo-5-(trifluoromethyl)benzoic acid participate in a variety of chemical reactions, demonstrating unique reactivity due to the presence of the iodine and trifluoromethyl groups. These reactions are often crucial in the synthesis of more complex molecules. For instance, Richter et al. (2021) discussed the structural characterization of similar compounds as precursors for the synthesis of new drug candidates, illustrating the diverse chemical reactivity of these compounds (Richter et al., 2021).

Scientific Research Applications

• Corrosion Inhibitors

  • Application: Benzoic acid derivatives have been studied as corrosion inhibitors for AISI 316 stainless steel in hydrochloric acid medium.
  • Method: The inhibition efficiency of these compounds was evaluated using weight loss, open circuit potential, potentiodynamic polarization method, electrochemical impedance spectroscopy, and scanning electron microscopy analysis.
  • Results: The results showed that the inhibition efficiency of these inhibitors increased with the increase in concentration.

• Co-crystal Engineering

  • Application: Benzoic acid derivatives are extensively employed in co-crystal engineering.
  • Method: These compounds have been extensively studied using experimental and computational techniques to understand the structure–property relations.
  • Results: Introduction of another functional group and its position is found to systematically influence the physical and chemical properties.

• Food Preservatives

  • Application: Benzoic acid and its derivatives are widely used as food preservatives.
  • Method: They are added to food products to inhibit the growth of fungi and bacteria.
  • Results: They have been found to be effective in preserving the freshness and extending the shelf life of food products.

• Pharmaceutical Applications

  • Application: Sodium benzoate, a salt of benzoic acid, is used as a treatment for urea cycle disorders.
  • Method: It works by binding to amino acids, which helps the body get rid of excess nitrogen.
  • Results: This treatment has been found to be effective in managing symptoms of urea cycle disorders.

• Antibacterial and Antifungal Preservatives

  • Application: Benzoic acid and its derivatives are commonly used as antibacterial and antifungal preservatives.
  • Method: These compounds are added to food, cosmetic, hygiene, and pharmaceutical products to inhibit the growth of bacteria and fungi.
  • Results: They have been found to be effective in preserving the freshness and extending the shelf life of these products.

• Flavoring Agents

  • Application: Benzoic acid and its derivatives are used as flavoring agents in food products.
  • Method: These compounds are added to food products to enhance their flavor.
  • Results: They have been found to be effective in improving the taste of food products.

Safety And Hazards

The compound is labeled with the GHS07 pictogram, indicating that it can cause harm if swallowed, inhaled, or if it comes into contact with skin. The associated hazard statements are H302, H315, H319, H332, and H335. Precautionary measures include avoiding breathing dust/fume/gas/mist/vapors/spray and washing thoroughly after handling.

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