71195-85-2 | Pentafluorophenyl acrylate

CAS:71195-85-2 | Pentafluorophenyl acrylate ,Description

Pentafluorophenyl acrylate (PFPa) is an important fluorinated monomer with a wide range of applications in the chemical and pharmaceutical industries. It is a versatile building block for the synthesis of polymers, copolymers, and other materials with unique properties. PFPa is also used as a reagent in organic synthesis, and is an important starting material in the production of pharmaceuticals, cosmetics, and specialty chemicals. In 
 

Scientific Research Applications

Synthesis of Multifunctional Polymers

Pentafluorophenyl acrylate is primarily used in the synthesis of multifunctional polymers. Eberhardt et al. (2005) demonstrated that polymers derived from pentafluorophenyl acrylate can be used as soluble polymeric active esters in the preparation of multifunctional materials. These polymers exhibit reactivity towards primary and secondary amines and alcohols, facilitating the creation of polymers with varied functional properties (Eberhardt, Mruk, Zentel, & Théato, 2005).

Reactive Microcapillary Printing

Arnold et al. (2014) explored the application of pentafluorophenyl acrylate in reactive microcapillary printing (R-μCaP). This technique involves covalently attaching poly(pentafluorophenyl acrylate) to silicon oxide, which can then be used to generate patterns of spatially resolved chemical functionality (Arnold, McNitt, Popik, & Locklin, 2014).

Functionalization through Radical Addition

Caddick et al. (2004) provided a novel route to functionalize pentafluorophenyl (PFP) acrylate through rapid intermolecular radical addition. This method yields a variety of active esters, which are susceptible to further functionalization by aminolysis, highlighting the versatility of PFP acrylate in chemical synthesis (Caddick, Hamza, Judd, Reich, Wadman, & Wilden, 2004).

Fabrication of Nanoporous Structures

Zhao et al. (2013) utilized block copolymers synthesized from poly(pentafluorophenyl (methyl)acrylates) for the fabrication of nanoporous thin films and fibers. These materials remain reactive to amine substitution, demonstrating their potential for various applications, including filtration and catalysis (Zhao, Gu, Thielke, Sterner, Tsai, Russell, Coughlin, & Théato, 2013).

Protein Purification

Son et al. (2018) developed reactive pentafluorophenyl acrylate (PFPA) polymer brushes for cleaner protein purification. These polymer brushes, grafted on silica particles, were used to immobilize antibodies forefficient protein separation, showcasing the potential of PFPA in biomedical applications (Son, Ku, Kim, Li, & Char, 2018).

Kinetic Studies in Polymerization

Alex et al. (2021) conducted kinetic investigations on the (co)polymerization of pentafluorophenyl (meth)acrylates, particularly for biomedical applications. This study offers insights into the polymerization behavior of pentafluorophenyl acrylate, which is crucial for producing advanced materials with precise properties (Alex, Ulbrich, Rosales-Guzmán, Weber, Schubert, & Guerrero‐Sanchez, 2021).

Orthogonal Click Chemistry for Surface Modification

Brooks et al. (2016) utilized poly(pentafluorophenyl acrylate) brushes for multifunctional surface manipulation. These brushes were patterned using reactive microcapillary printing and other click chemistries, demonstrating the ability of pentafluorophenyl acrylate to create complex surface motifs with diverse chemical functionalities (Brooks, Yatvin, McNitt, Reese, Jung, Popik, & Locklin, 2016).

Thiol-Reactive Functional Polymers

Noy et al. (2015) described the synthesis and postpolymerization modification of thiol-reactive (meth)acrylate polymers containing pentafluorophenyl groups. These polymers underwent efficient thiol-para-fluoro substitution reactions, showcasing the adaptability of pentafluorophenyl acrylate in creating responsive polymer systems (Noy, Koldevitz, & Roth, 2015).

Optical Properties in Polymerization

Blazejewski et al. (1999) studied the bulk polymerization of pentafluorophenyl acrylate and its copolymers, focusing on their thermal and optical properties. This research contributes to understanding the material properties of pentafluorophenyl acrylate polymers, which are essential for applications in optics and electronics (Blazejewski, Hofstraat, Lequesne, Wakselman, & Wiersum, 1999).

CO2-Responsive Nanofibers

Lin et al. (2018) developed CO2-responsive nanofibers from photo-cross-linked poly(pentafluorophenyl acrylate). These nanofibers, modified with histamine, show a reversible hydrophobic-hydrophilic transition in response to CO2, suggesting their potential use in environmental sensing and responsive materials (Lin, Shang, & Théato, 2018).

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