722-92-9 | 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

CAS:722-92-9 | 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol ,Description

2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, or 2-AP, is an organic compound of the aminophenol family. It is a white, odorless, crystalline solid with a melting point of 73.5 °C. 2-AP is a versatile compound that is used in a variety of laboratory experiments and scientific research applications. It is commonly used in organic synthesis, as a surfactant, and as a precursor to other compounds. Additionally, 2-AP has been studied for its potential biochemical and physiological effects. 
 

Scientific Research Applications

Synthesis and Material Development

Research by Li, Shen, and Zhang (2015) demonstrated the synthesis of 2-(4-hydroxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol through the reaction of phenol with hexafluoroacetone. The study highlighted the potential of this compound in the synthesis of organic fluoro-containing polymers due to its deprotonatable hydroxyl groups (Shi-Juan Li, Daniel Y. Shen, & Chao-Zhi Zhang, 2015).

Similarly, Lv Chun (2009) described a process involving 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol in the synthesis of Bisphenol AF, a precursor for various high-performance polymers. This method displayed high yield and efficiency in creating fluoro-containing compounds (Lv Chun, 2009).

Catalysis and Chemical Reactions

In the field of catalysis, Shibuya et al. (2021) explored the use of 1,1,1,3,3,3-hexafluoropropan-2-ol as a solvent in N-Hydroxyphthalimide-catalyzed benzylic C-H amination, demonstrating its critical role in chemoselectivity. This indicates the compound's potential in facilitating specific chemical transformations (Shibuya, Orihashi, Li, & Yamamoto, 2021).

Polymer Science

In polymer science, Fang, Kita, and Okamoto (2000) synthesized aromatic hyperbranched polyimides using a compound structurally related to 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. Their research focused on the synthesis of polymers with potential applications in gas separation (J. Fang, H. Kita, & K. Okamoto, 2000).

Electrochemistry

Research in electrochemistry by Imada et al. (2018) utilized 1,1,1,3,3,3-hexafluoropropan-2-ol in a metal- and reagent-free dehydrogenative benzyl-aryl cross-coupling process. This study emphasizes the role of hexafluoropropan-2-ol in enabling sustainable chemical transformations (Y. Imada, Röckl, Wiebe, Gieshoff, Schollmeyer, Chiba, Franke, & Waldvogel, 2018).

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