73602-61-6 | Triethylamine trihydrofluoride

CAS:73602-61-6 | Triethylamine trihydrofluoride ,Description

Triethylamine trihydrofluoride (TEA-THF) is a chemical compound composed of three ethylamine molecules and one hydrofluoride molecule. It is a colorless, volatile liquid with a faint, ammonia-like odor. TEA-THF has a variety of uses in scientific research, including in organic synthesis, as a catalyst, and as a reagent in the production of other compounds. 
 

Scientific Research Applications

• Fluorinating Agent: It is a versatile fluorinating agent used in nucleophilic substitutions, electrophilic additions, electrofluorinations, and the deprotection of silylethers (Haufe, 1996).
• Electrochemical Selective Fluorination: As a high-boiling point, non-corrosive reagent, it is utilized in electrochemical selective fluorination of organic compounds, relevant in organic synthesis (Zhang Bao-gui, 2008).
• Inhibition of Liver Enzymes: Triethylamine and similar alkylamines can inhibit rat liver sulfotransferase activities towards androgens, indicating potential use in drug discovery and development (Matsui, Takahashi, & Homma, 1993).
• Synthesis of Pharmaceutical Compounds: Used in the synthesis of trifluoromethylamines, which are significant in the development of various pharmaceutical drugs (Kanie, Mizuno, Kuroboshi, & Hiyama, 1998).
• RNA Synthesis: It aids in the efficient synthesis and purification of biologically active RNA oligoribonucleotides (Sproat, Colonna, Mullah, Tsou, Andrus, Hampel, & Vinayak, 1995).
• Chemical Synthesis: Facilitates ultrasound-assisted one-pot synthesis of certain chemical compounds, providing cost-effective and environmentally friendly methods (Nabid, Rezaei, Ghahremanzadeh, & Bazgir, 2010).
• Gas Sensing: Used in the development of sensors for triethylamine gas detection, which is important in food safety inspection and environmental monitoring (Zhou, Lu, Chen, Li, Wei, Zi, Zeng, Zhang, Zhang, Zhu, & Liu, 2020).
• Health Effects Study: Its health effects have been studied through inhalation exposure experiments in rats and mice, showing no significant long-term health impacts (2018).

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