74427-22-8 | 2,2-Difluoroethyl trifluoromethanesulfonate

CAS:74427-22-8 | 2,2-Difluoroethyl trifluoromethanesulfonate ,Description

2,2-Difluoroethyl trifluoromethanesulfonate (DFEMS) is an organic compound that has been widely used in various scientific research applications. It is a versatile compound that can be used in a variety of ways, from synthesizing new molecules to studying the effects of different compounds on the biochemical and physiological systems of living organisms. 
 

Scientific Research Applications

• Lewis Acid Catalyst in Acylation of Alcohols: Scandium trifluoromethanesulfonate is an extremely active Lewis acid catalyst for acylating alcohols with acid anhydrides. It is particularly effective for selective macrolactonization of omega-hydroxy carboxylic acids (Ishihara, Kubota, Kurihara, & Yamamoto, 1996).
• Use in Electrophilic Aromatic Substitution and Other Reactions: Trifluoromethanesulfonic acid is used in electrophilic aromatic substitution reactions, carbon-carbon and carbon-heteroatom bond formations, isomerizations, syntheses of carboand heterocyclic structures, among other reactions in organic synthesis (Kazakova & Vasilyev, 2017).
• Catalyst for Inducing Cyclisation of Homoallylic Sulfonamides: Trifluoromethanesulfonic acid acts as a catalyst in the cyclisation of homoallylic sulfonamides to form pyrrolidines and other polycyclic systems (Haskins & Knight, 2002).
• Cross-Coupling Reactions with Organo-metallics: Vinyl and aryl trifluoromethanesulfonates, due to their facile preparation, undergo cross-coupling reactions with organo-metallics, exhibiting superior regio- and diastereoselectivity in reactions like the Heck reaction (Ritter, 1993).
• Applications in Organic Synthesis: Trifluoromethanesulfonic anhydride is used for electrophilic activation and conversion of amides, sulfoxides, and phosphorus oxides, and as a radical trifluoromethylation and trifluoromethylthiolation reagent (Qin, Cheng, & Jiao, 2022).
• Catalysis of Aminolysis of 1,2-Epoxides: Lanthanide(III) trifluoromethanesulfonates are efficient catalysts for the aminolysis of 1,2-epoxides, leading to the formation of β-amino alcohols with high selectivity and yield (Chini, Crotti, Favero, Macchia, & Pineschi, 1994).
• Efficient Reduction of Hydroxy Substituted Compounds: Trialkylborane/trifluoromethanesulfonic acid is used for the selective reduction of hydroxy substituted carboxylic acids, ketones, and aldehydes to yield corresponding carbonyl compounds (Olah & Wu, 1991).

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