749931-20-2 | 4-broMo-2-fluoro-5-Methoxy-benzaldehyde

CAS:749931-20-2 | 4-broMo-2-fluoro-5-Methoxy-benzaldehyde,Description

4-Bromo-2-fluoro-5-methoxybenzaldehyde is a compound with the CAS Number: 749931-20-2. It has a molecular weight of 233.04 and its IUPAC name is 4-bromo-2-fluoro-5-methoxybenzaldehyde.

Molecular Structure Analysis

The molecular formula of 4-Bromo-2-fluoro-5-methoxybenzaldehyde is C8H6BrFO2. The InChI code is 1S/C8H6BrFO2/c1-12-8-2-5(4-11)7(10)3-6(8)9/h2-4H,1H3.

Physical And Chemical Properties Analysis

4-Bromo-2-fluoro-5-methoxybenzaldehyde is a solid substance. More specific physical and chemical properties such as melting point, boiling point, and density are not provided in the search results.

Scientific Research Applications

Synthesis and Chemical Studies

4-Bromo-2-fluoro-5-methoxybenzaldehyde serves as an intermediate in various synthetic routes for producing complex organic compounds. For instance, its derivatives have been used in the synthesis of Methyl 4-Bromo-2-methoxybenzoate through a multi-step process involving bromination, hydrolysis, cyanidation, methoxylation, and esterification, achieving high yield and purity (Chen Bing-he, 2008). Similarly, hydroxylated and methoxylated polybrominated diphenyl ethers, important in environmental chemistry, have been synthesized from brominated phenoxybenzaldehydes prepared via coupling of various fluorobenzaldehydes for use as analytical and toxicological reference standards (G. Marsh, R. Stenutz, A. Bergman, 2003).

Drug Discovery and Medicinal Chemistry

In the realm of drug discovery, the compound has facilitated the development of key intermediates. For example, 5-bromo-2-methylamino-8-methoxyquinazoline, a crucial intermediate in drug development, was synthesized from 6-bromo-2-fluoro-3-methoxybenzaldehyde, showcasing improvements in synthesis routes through the telescoping process for efficient drug compound production (K. Nishimura, T. Saitoh, 2016).

Bioconversion and Environmental Impact

Research on the white rot fungus Bjerkandera adusta highlighted the bioconversion of halogenated organic compounds, identifying novel brominated methoxybenzaldehyde metabolites. This study contributes to understanding fungal metabolism's role in environmental detoxification processes (H. Beck, F. R. Lauritsen, J. Patrick, R. Cooks, 2000).

Liquid Crystal Synthesis

The compound also plays a role in the synthesis of liquid crystal molecules, demonstrating the diversity of applications ranging from organic chemistry to materials science. The synthesis and characterization of fluorinated 1,5-benzothiazepines and pyrazolines from 4-Bromo-2-fluorobenzaldehyde reveal its utility in creating novel liquid crystalline materials, highlighting the compound's versatility in contributing to advances in display technologies and optical materials (S. G. Jagadhani, S. G. Kundlikar, B. Karale, 2015).

Safety And Hazards

The compound is labeled with the GHS07 pictogram and the signal word "Warning". Hazard statements include H302. Precautionary statements include P261, P280, P305+P351+P338, P304+P340, P405, and P501.

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