753-90-2 | 2,2,2-Trifluoroethylamine

CAS:753-90-2 | 2,2,2-Trifluoroethylamine ,Description

2,2,2-Trifluoroethylamine (TFEA) is a versatile organic compound with a wide range of applications in both scientific research and industrial processes. It is a colorless, volatile liquid that is miscible with water and most organic solvents. It is a strong nucleophile and is used in a variety of reactions, including alkylations, acylations, and aminations. It is also used as a catalyst in the synthesis of pharmaceuticals, polymers, and other organic compounds.
 

Scientific Research Applications

Quantification in Polymer Particles

2,2,2-Trifluoroethylamine has been utilized in the quantification of fluorine content in polymer particles. This application is significant in creating reference materials for metrological traceability of surface group quantifications. The polymer particles labelled with 2,2,2-trifluoroethylamine were quantified using XPS and solid-state NMR, demonstrating overlapping sensitivity ranges and reliability (Hennig et al., 2015).

Investigation in Rotational Spectra

The compound has been a subject of research in high-resolution microwave Fourier transform spectroscopy, particularly in studying the 14N-hyperfine structure of trans-2,2,2-trifluoroethylamine. This study provided insights into the electronic surroundings of nitrogen in the molecule, influenced by fluorine atoms through hydrogen bridge bonds (Keussen & Dreizler, 1991).

Reagent for Organic Synthesis

2,2,2-Trifluorodiazoethane, a derivative of 2,2,2-trifluoroethylamine, has been extensively used as a reagent in the synthesis of various trifluoromethyl-substituted organic molecules. It has gained attention for its rapid synthesis capabilities in both academic and industrial research settings (Mykhailiuk, 2020).

Synthesis of Fluorinated Ureas

The addition of 2,2,2-trifluoroethylamine to aroxysulfonyl isocyanates has been identified as an effective method for preparing fluorinated aroxysulfonyl ureas. This synthesis approach yields high reaction efficiency (Kateb et al., 1999).

Passivation in Perovskite Solar Cells

In the field of renewable energy, specifically perovskite solar cells, fluoroethylamine (including its trifluoroethylamine variant) has been used to passivate defects in perovskite films. This application enhances device performance by reducing nonradiative recombination and improving carrier lifetime, contributing significantly to higher efficiency and stability of solar cells (Su et al., 2021).

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