76469-41-5 | 2,3,5-Trifluoropyridine

CAS:76469-41-5 | 2,3,5-Trifluoropyridine ,Description

2,3,5-Trifluoropyridine (2,3,5-TFP) is an organic compound that is widely used in the chemical industry for a variety of purposes. It is a colorless liquid with a pungent odor and is a derivative of pyridine, a nitrogen-containing aromatic compound. 2,3,5-TFP is used as a reactant in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a solvent for various applications.
 

Scientific Research Applications

Synthesis Applications

• Synthesis of Derivatives: 2,3,5-Trifluoropyridine serves as a precursor in the synthesis of various derivatives. For example, it's involved in the preparation of 2,3-Difluoro-5-chloropyridine using potassium fluoride and a phase transfer catalyst (Zhou Hong-feng, 2007). Another study describes the synthesis of 2,4,6-Triarylpyridine derivatives, highlighting the relevance of pyridines in supramolecular chemistry and their applications in various biological and pharmaceutical properties (B. Maleki, 2015).

Structural and Energetic Analysis

• Crystal Structures: The crystal structures of various fluorinated pyridines, including 2,3,5-Trifluoropyridine, were analyzed to understand their arrangement and intermolecular interaction energy. This study provides insight into the aggregation behavior of these compounds (V. Vasylyeva et al., 2012).

Molecular Interaction Studies

• Interaction with DNA and Microbial Activity: Spectroscopic and optical studies of 5-Bromo-2-(trifluoromethyl)pyridine, a related compound, involved density functional theory to understand its interaction with DNA and its antimicrobial activities. Such studies highlight the potential biological interactions of fluorinated pyridines (H. Vural, M. Kara, 2017).

Miscellaneous Applications

• Fluorination Effects on Pyridines: A study on the rotational spectra of 2,3,6-trifluoropyridine explored the impact of fluorination on the ring geometry of the compound, providing insights into the structural dynamics influenced by fluorine atoms (Junhua Chen et al., 2020).

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