771-60-8 | Pentafluoroaniline

CAS:771-60-8 | Pentafluoroaniline ,Description

Pentafluoroaniline, also known as pentafluorobenzene, is a highly fluorinated aromatic compound with the chemical formula C6F5NH2. It is a colorless liquid with a pungent odor and a boiling point of 46.1 °C. Pentafluoroaniline is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It also has applications in materials science, such as in the production of polymers and in the synthesis of nanomaterials.
 

Scientific Research Applications

Theoretical Studies and Spectroscopy

• PFA has been studied for its interesting interaction between fluorine and an aromatic ring. The effects of fluorine atoms on the geometrical and electronic properties of PFA have been explored through theoretical Raman and infrared spectra analyses (Wojciechowski, 2013).
• Investigations into the infrared and Raman spectra of PFA have provided insights into the vibrations of the C6F5X group, which are similar across related molecules with different X substituents (Faniran & Shurvell, 1975).

Chemical Reactions and Electron Attachment

• PFA undergoes rapid fluoride elimination when reacting with H and OH radicals in aqueous solutions, forming various radical species. This reaction is significant in understanding the chemical behavior of PFA under different conditions (Shoute, Mittal, & Neta, 1996).
• Research on dissociative electron attachment (DEA) to PFA reveals the role of rearrangement and hydrogen-bonded intermediates in the DEA process, highlighting the utility of PFA in chemical control studies (Ómarsson et al., 2012) .

Synthesis and Derivatization

• PFA has been utilized in the synthesis of various compounds. For instance, the preparation and decarbonylation of pentafluoroformanilide, which is derived from PFA, have been documented, expanding the scope of synthetic applications of PFA (Banks, Haszeldine, & Willoughby, 1975).
• PFA's reactions with aromatic trihalomethyl derivatives in the presence of AlCl3 have been explored, revealing its potential in the synthesis of imidoyl chlorides and other complex organic compounds (Petrova et al., 1994).

Photophysical Studies

• In the field of optical imaging and drug delivery, cyanine reactivity, which involves compounds like PFA, has been harnessed. Studies have focused on reaction discovery to address limitations of long-wavelength fluorophores, leading to advancements in imaging technologies (Gorka, Nani, & Schnermann, 2018).

Material Science

• PFA has been studied in the context of dielectric spectroscopy, contributing to our understanding of relaxation in rotationally disordered phases of hexa-substituted benzenes. Such studies are significant in material science, particularly in the study of molecular dynamics in solid states (Murthy & Singh, 2014).

More Information