77613-65-1 | 1-Bromomethyl-2,2-difluorocyclopropane

CAS:77613-65-1 | 1-Bromomethyl-2,2-difluorocyclopropane ,Description

1-Bromomethyl-2,2-difluorocyclopropane (1-Br-2,2-difluorocyclopropane), is a halogenated cyclopropane compound. It has a molecular formula of C3H4BrF2 and a molecular weight of 155.96 g/mol. 1-Br-2,2-difluorocyclopropane is a colorless liquid that is slightly soluble in water and is soluble in many organic solvents. This compound has a wide range of applications in the fields of chemistry, biochemistry, and medicine, and has been studied extensively in recent years.
 

Scientific Research Applications

Electrochemical Synthesis

1-Bromomethyl-2,2-difluorocyclopropane and related compounds have been studied in the context of electrochemical synthesis. Hazard, Jaouannet, and Tallec (1982) explored the electrochemical behaviors of similar bromocyclopropanes in the presence of alkaloids. They found that these interactions facilitate the cleavage of carbon-halogen bonds and can produce optically active products through asymmetric electrochemical synthesis (Hazard, Jaouannet, & Tallec, 1982).

Alkylation Reagent

Steinbeck (1979) discussed the use of 1-Bromomethyl-2,2-difluorocyclopropane as an alkylation reagent. The reaction with nucleophiles yields substitution products while preserving the dichlorocyclopropane system (Steinbeck, 1979).

Synthesis of gem-Bromochlorocyclopropanes

Balcerzak and Jończyk (1991) presented a method for synthesizing substituted 1-bromo-1-chlorocyclopropanes from dibromomethane and other compounds. This process uses aqueous potassium hydroxide and tetrabutylammonium hydrogen sulfate as a catalyst (Balcerzak & Jończyk, 1991).

Bicyclo[4.3.0]nonenes and Bicyclo[4.4.0]decenes Synthesis

Ang et al. (1996) explored the cyclization of various 2-bromo dienes under palladium catalysis, leading to bicyclo[4.3.0]nonene and bicyclo[4.4.0]-decene derivatives. This process involves an intramolecular Heck reaction without opening the cyclopropyl group (Ang et al., 1996).

Vibrational Spectra and Conformations

Wurrey, Krishnamoorthi, Pechsiri, and Kalasinsky (1982) studied the infrared and Raman spectra of (bromomethyl)cyclopropane, providing insights into its conformations and stability (Wurrey, Krishnamoorthi, Pechsiri, & Kalasinsky, 1982).

Preparation of 1-Aryl-2-bromo-3,3-difluorocyclopropenes

Lin, Chen, and Lee (2004) discussed a method for preparing 1-Aryl-2-bromo-3,3-difluorocyclopropanes, highlighting an alternative synthetic pathway and the potential for further conversions to other compounds (Lin, Chen, & Lee, 2004).

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