80351-58-2 | Bromodifluoromethanesulfonylbenzene

CAS:80351-58-2 | Bromodifluoromethanesulfonylbenzene ,Description

Bromodifluoromethanesulfonylbenzene, also known as BDFMS, is an important reagent used in organic synthesis. It is a versatile reagent that can be used for various purposes, including the synthesis of a variety of compounds, the determination of the structure of unknown compounds, and the study of the mechanism of reactions. BDFMS is also used in a variety of analytical techniques, such as gas chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy. Additionally, BDFMS has been used in pharmaceutical research and development, as it can be used to synthesize a variety of drug molecules. 
 

Scientific Research Applications

Synthesis and Chemical Applications

• Friedel–Crafts-Type Alkylation: Bromodifluoro(phenylsulfanyl)methane, a related compound to Bromodifluoromethanesulfonylbenzene, has been used in a Friedel–Crafts-type alkylation process. This process is crucial in the synthesis of thioesters, benzophenones, and naturally occurring xanthone derivatives (Kuhakarn et al., 2011) .
• Synthesis of Imaging Agents: In a related context, bromobenzene derivatives have been used in the synthesis of imaging agents like [18F]FP-β-CIT, important in medical imaging (Klok et al., 2006).
• Metal-Organic Frameworks (MOFs): Sulfonic acid analogs of terephthalic and trimesic acid, derived from bromobenzene compounds, have been utilized to form MOFs with enhanced thermal stability, showcasing the potential of Bromodifluoromethanesulfonylbenzene derivatives in materials science (Mietrach et al., 2009).
• Nucleophilic (Phenylsulfonyl)difluoromethylation: This technique, applicable to alkyl halides, uses compounds like (phenylsulfonyl)difluoromethylated alkanes to create gem-difluoroalkenes and trifluoromethyl compounds. These products are significant in various chemical synthesis processes (Zhu et al., 2010).

Diagnostic and Medical Imaging

• Contrast Agents in Imaging: Perfluorochemicals (PFCs), which include bromine atoms like in perfluoroocytlbromide (PFOB), serve as contrast agents in ultrasound and computed tomography imaging. Their unique chemical structure allows for diverse medical imaging applications (Mattrey & Lo, 1988).

Materials Science and Engineering

• Polymer Science: In polymer chemistry, sulfonyl (trifluoromethanesulfonyl)imide functionalized (co)polymers have been synthesized using potassium sulfonyl derivatives. These derivatives are key in the post-polymerization functionalization of polymers, indicating potential applications of Bromodifluoromethanesulfonylbenzene in this field (Tintaru et al., 2017).
• Liquid Crystalline Properties: Long-chain imidazolium salts, including those with bromide and trifluoromethanesulfonate, have been studied for their liquid crystalline properties. These salts form lamellar structures and smectic phases, useful in materials engineering (Bradley et al., 2002) .

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