80522-42-5 | Triisopropylsilyl trifluoromethanesulfonate

CAS:80522-42-5 | Triisopropylsilyl trifluoromethanesulfonate ,Description

Triisopropylsilyl trifluoromethanesulfonate (TIPS-Tf) is an organosilicon compound that is used in a variety of laboratory experiments, including organic synthesis, biochemistry, and pharmacology. TIPS-Tf is a highly useful reagent due to its wide range of reactivity and its ability to form strong bonds with organic compounds. TIPS-Tf is also a relatively inexpensive reagent, making it a popular choice for laboratory experiments.
 

Synthesis Method Details

Design of the Synthesis Pathway
The synthesis pathway of Triisopropylsilyl trifluoromethanesulfonate involves the reaction of Triisopropylsilanol with Trifluoromethanesulfonic anhydride in the presence of a catalyst.

Starting Materials
Triisopropylsilanol, Trifluoromethanesulfonic anhydride, Catalyst

Reaction
Step 1: Add Triisopropylsilanol to a reaction flask, Step 2: Add Trifluoromethanesulfonic anhydride to the reaction flask slowly while stirring, Step 3: Add a catalyst to the reaction mixture, Step 4: Heat the reaction mixture to 50-60°C and stir for several hours, Step 5: Cool the reaction mixture to room temperature and add water slowly while stirring, Step 6: Extract the product with an organic solvent such as diethyl ether, Step 7: Dry the organic layer with anhydrous magnesium sulfate, Step 8: Filter the organic layer and concentrate the product under reduced pressure to obtain Triisopropylsilyl trifluoromethanesulfonate as a colorless liquid.

Scientific Research Application

Triisopropylsilyl trifluoromethanesulfonate is used extensively in scientific research, particularly in organic synthesis and biochemistry. In organic synthesis, Triisopropylsilyl trifluoromethanesulfonate is used as a protecting group for a variety of functional groups, such as alcohols, amines, and thiols. In biochemistry, Triisopropylsilyl trifluoromethanesulfonate is used to label proteins and other biomolecules, which allows researchers to track the movement of these molecules in vivo. Triisopropylsilyl trifluoromethanesulfonate can also be used to synthesize peptides and other organic compounds.
 

Mechanism of Action

Triisopropylsilyl trifluoromethanesulfonate works by forming strong covalent bonds with organic compounds. The bonds formed by Triisopropylsilyl trifluoromethanesulfonate are highly stable and can withstand a variety of conditions, including high temperatures and harsh chemicals. This makes Triisopropylsilyl trifluoromethanesulfonate an ideal reagent for a wide range of laboratory experiments.
 

Biochemical and Physiological Effects

Triisopropylsilyl trifluoromethanesulfonate has been used in a variety of studies to investigate the biochemical and physiological effects of certain compounds. For example, Triisopropylsilyl trifluoromethanesulfonate has been used to study the effects of certain drugs on the brain. Triisopropylsilyl trifluoromethanesulfonate has also been used to study the effects of certain compounds on the immune system.
 

Advantages and Limitations for Lab Experiments

Triisopropylsilyl trifluoromethanesulfonate has several advantages for laboratory experiments. It is relatively inexpensive, easy to use, and can form strong bonds with organic compounds. Additionally, Triisopropylsilyl trifluoromethanesulfonate is relatively inert and can withstand a variety of conditions, making it an ideal reagent for a wide range of experiments. However, Triisopropylsilyl trifluoromethanesulfonate can be difficult to remove from a reaction mixture, making it difficult to purify the desired product.
 

Future Directions

Future research on Triisopropylsilyl trifluoromethanesulfonate could focus on improving the synthesis and purification processes. Additionally, Triisopropylsilyl trifluoromethanesulfonate could be used to study the effects of certain compounds on the environment, as well as the effects of certain drugs on the body. Finally, Triisopropylsilyl trifluoromethanesulfonate could be used to develop new methods for the synthesis of organic compounds, as well as new methods for the labeling of proteins and other biomolecules.

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