815-06-5 | N-Methyl-2,2,2-trifluoroacetamide

CAS:815-06-5 | N-Methyl-2,2,2-trifluoroacetamide ,Description

N-Methyl-2,2,2-trifluoroacetamide (NMTFAA) is a synthetic organic compound with a wide range of applications in scientific research and laboratory experiments. It is a colorless, odorless, and non-volatile liquid with a molecular weight of 147.05 g/mol. NMTFAA has a melting point of -48°C and a boiling point of 65°C, making it a highly stable compound. NMTFAA is a versatile molecule that can be used in a variety of experiments and applications, including organic synthesis, chromatography, and spectroscopy.
 

Scientific Research Applications

Trifluoroacetylation Applications

• Trifluoroacetylation of Amine, Hydroxyl, and Thiol Groups: NMTFA is used for trifluoroacetylation of amine, hydroxyl, and thiol groups under mild, non-acidic conditions, resulting in neutral trifluoroacetamides. This technique is particularly useful in trace analysis due to the volatility and sharp elution of these compounds in gas chromatography (Donike, 1973).
• Carbohydrate Analysis: NMTFA has been applied in the rapid trifluoroacetylation of carbohydrates in a homogeneous medium. The stability of the derivatives in this process facilitates direct use in gas-liquid chromatography (GLC) for analyzing mixtures of trifluoroacetylated cyclitols, hexoses, alditols, and oligosaccharides (Englmaier, 1985).

Derivatization Techniques

• Stereospecific Derivatization: NMTFA is utilized in the stereospecific derivatization of amphetamines, phenol alkylamines, and hydroxyamines, aiding in the separation and quantification of enantiomers through capillary GC/MS (Shin & Donike, 1996).
• Derivatization of Phenolalkylamines: NMTFA facilitates the preparation of N-trifluoroacetyl-O-trimethylsilyl-phenolalkylamines, useful in gas chromatography and mass spectrometry for identification purposes (Donike, 1975).

Analytical Applications

• Gas Chromatography and Mass Spectrometry: NMTFA is employed in the preparation of N-mono-trifluoroacetylated derivatives of amphetamines and analogues for analysis via gas chromatography and mass spectrometry (Brettell, 1983).
• Synthesis and Analysis of Tetraaza[3.3.3.3]meta- and Paracyclopanes: NMTFA is used in the synthesis of these compounds, demonstrating its utility in organic synthesis (Shinmyozu et al., 1993).
• Quantification of Disinfection By-products in Drinking Water: NMTFA has been utilized in a simplified analytical method for quantifying disinfection by-products in drinking water, an important step in ensuring water safety (Kubwabo et al., 2009).

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