84349-27-9 | Sodium bromodifluoroacetate

CAS:84349-27-9 | Sodium bromodifluoroacetate ,Description

Sodium bromodifluoroacetate (NaBrDFA) is a colorless, odorless, and water-soluble organic compound. It is a bromine-containing derivative of difluoroacetic acid and is used in a variety of scientific research applications. NaBrDFA is a versatile compound with a wide range of applications in biochemistry and physiology. It is used as a reagent in synthetic organic chemistry and has been studied for its potential as an enzyme inhibitor and a drug delivery agent.
 

Scientific Research Applications

• Organic Synthesis and Chemical Reactions:
  • Synthesis of 2,2-Difluoro-3-hydroxy Esters: Sodium bromodifluoroacetate is used in the synthesis of 2,2-difluoro-3-hydroxy esters with high yields under mild conditions, particularly useful in pharmaceutical and agricultural chemistry (Shen & Qi, 1994).
  • Difluoromethylated Arenes Synthesis: It catalyzes the reaction of aryl boronic acids to create difluoromethylated arenes, valuable in drug discovery (Feng et al., 2016).
  • Triple Mode of Chemical Reactivity: Exhibits a versatile chemical reactivity profile, facilitating base-promoted N-difluoromethylation and other alkylation reactions (Polley et al., 2018).
• Environmental and Biological Applications:
  • Possum Control: Sodium monofluoroacetate, a related compound, is an essential tool for controlling possum populations in certain environments (Eason et al., 1993).
  • Detection of Biological Pollutants: Techniques involving fluorinated compounds like sodium bromodifluoroacetate are used in the sensitive and selective detection of biological pollutants, crucial for environmental monitoring and food safety (Mehta & Waterland, 2020).
• Pharmaceuticals and Drug Development:
  • Synthesis of Carbamoyl Fluorides: Difluorocarbene, derived from compounds like sodium bromodifluoroacetate, is used to synthesize carbamoyl fluorides, which have applications in pharmaceuticals (Baars et al., 2016).
  • Preparation of Difluoromethylene Functionalized Sulfones: Functionalized sulfones are valuable in drug discovery and development, synthesized using bromodifluoroacetate or acetamide (Yang & Burton, 1992) .

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