851386-33-9 | 5,6-DIFLUORO PYRIDINE-3-CARBOXYLIC ACID

CAS:851386-33-9 | 5,6-DIFLUORO PYRIDINE-3-CARBOXYLIC ACID,Description

Fluoropyridines are a type of aromatic compound where one or more hydrogen atoms on the pyridine ring are replaced by fluorine . They are known for their interesting and unusual physical, chemical, and biological properties due to the presence of the strong electron-withdrawing fluorine substituents in the aromatic ring .

Synthesis Analysis

The synthesis of fluoropyridines often involves halogen exchange reactions, where a halogen atom (such as chlorine or bromine) in a halopyridine compound is replaced by a fluorine atom . The Umemoto and Balz-Schiemann reactions are some of the methods used for the synthesis of fluoropyridines .

Chemical Reactions Analysis

Fluoropyridines are generally less reactive than their chlorinated and brominated analogues due to the strong electron-withdrawing nature of the fluorine substituents . They can undergo various reactions such as substitution reactions .

Physical And Chemical Properties Analysis

The physical and chemical properties of fluoropyridines can vary widely depending on their specific structure. Generally, they have reduced basicity compared to non-fluorinated pyridines .

Scientific Research Applications

• Synthesis of Various Compounds

  • Field : Organic Chemistry
  • Application : 5,6-difluoropyridine-3-carboxylic Acid can be used in the synthesis of various compounds.
  • Method : The specific methods of synthesis would depend on the target compound. Generally, it involves reactions with various reagents under controlled conditions .
  • Results : The outcome is the formation of various compounds, which can be used in further reactions or for various applications.

• Synthesis of Drugs

  • Field : Pharmaceutical Chemistry
  • Application : Fluorinated pyridines, like 5,6-difluoropyridine-3-carboxylic Acid, can be used in the synthesis of drugs .
  • Method : The methods of synthesis would depend on the specific drug being synthesized. It generally involves reactions with various reagents under controlled conditions .
  • Results : The outcome is the formation of drug molecules, which can be used for therapeutic purposes .

• Synthesis of Materials

  • Field : Material Science
  • Application : 5,6-difluoropyridine-3-carboxylic Acid can be used in the synthesis of various materials.
  • Method : The specific methods of synthesis would depend on the target material. It generally involves reactions with various reagents under controlled conditions.
  • Results : The outcome is the formation of various materials, which can be used for various applications.

• Synthesis of Fluorinated Pyridines

  • Field : Organic Chemistry
  • Application : 5,6-difluoropyridine-3-carboxylic Acid can be used in the synthesis of fluorinated pyridines .
  • Method : The specific methods of synthesis would depend on the target compound. Generally, it involves reactions with various reagents under controlled conditions .
  • Results : The outcome is the formation of fluorinated pyridines, which can be used in further reactions or for various applications .

• Nanotechnology and Polymers

  • Field : Nanotechnology
  • Application : Carboxylic acids like 5,6-difluoropyridine-3-carboxylic Acid can be used in nanotechnology and polymers .
  • Method : The methods of application would depend on the specific area of nanotechnology or polymer science. It generally involves reactions with various reagents under controlled conditions .
  • Results : The outcome is the formation of various nanomaterials or polymers, which can be used for various applications .

• Preparation of Poly (pyridine ether)s

  • Field : Polymer Chemistry
  • Application : 2,6-Difluoropyridine, a similar compound to 5,6-difluoropyridine-3-carboxylic Acid, has been used in the preparation of poly (pyridine ether)s .
  • Method : The method involves polycondensation with silylated 1,1,1- tris (4-hydroxyphenyl)ethane .
  • Results : The outcome is the formation of poly (pyridine ether)s .

• Synthesis of F 18 Substituted Pyridines

  • Field : Radiotherapy and Cancer Research
  • Application : Methods for synthesis of F 18 substituted pyridines for local radiotherapy of cancer and other biological active compounds are also presented .
  • Method : The specific methods of synthesis would depend on the target compound. Generally, it involves reactions with various reagents under controlled conditions .
  • Results : The outcome is the formation of F 18 substituted pyridines, which present a special interest as potential imaging agents for various biological applications .

• Modification of Nanoparticles and Nanostructures

  • Field : Nanotechnology
  • Application : Carboxylic acids like 5,6-difluoropyridine-3-carboxylic Acid can be used as surface modifiers to promote the dispersion and incorporation of metallic nanoparticles or carbon nanostructures .
  • Method : The methods of application would depend on the specific area of nanotechnology. It generally involves reactions with various reagents under controlled conditions .
  • Results : The outcome is the modification of the surface of nanoparticles and nanostructures, which can be used for various applications .

• Catalytic and Non-catalytic Amidation

  • Field : Organic Chemistry
  • Application : Carboxylic acids can be used in catalytic and non-catalytic amidation .
  • Method : The methods of application would depend on the specific reaction. It generally involves reactions with various reagents under controlled conditions .
  • Results : The outcome is the formation of amide bonds in good to excellent yields .

Safety And Hazards

Like many chemical compounds, fluoropyridines can pose certain hazards. They may cause skin and eye irritation, and may be harmful if inhaled or swallowed .

Future Directions

Fluoropyridines have potential applications in various fields, including medicine and agriculture . They are of interest in the development of new pharmaceuticals and agrochemicals .

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