851386-33-9 | 5,6-DIFLUORO PYRIDINE-3-CARBOXYLIC ACID

CAS:851386-33-9 | 5,6-DIFLUORO PYRIDINE-3-CARBOXYLIC ACID,Description

Fluoropyridines are a type of aromatic compound where one or more hydrogen atoms on the pyridine ring are replaced by fluorine. They are known for their interesting and unusual physical, chemical, and biological properties due to the presence of the strong electron-withdrawing fluorine substituents in the aromatic ring.

Synthesis Analysis

The synthesis of fluoropyridines often involves halogen exchange reactions, where a halogen atom (such as chlorine or bromine) in a halopyridine compound is replaced by a fluorine atom. The Umemoto and Balz-Schiemann reactions are some of the methods used for the synthesis of fluoropyridines.

Chemical Reactions Analysis

Fluoropyridines are generally less reactive than their chlorinated and brominated analogues due to the strong electron-withdrawing nature of the fluorine substituents. They can undergo various reactions such as substitution reactions.

Physical And Chemical Properties Analysis

The physical and chemical properties of fluoropyridines can vary widely depending on their specific structure. Generally, they have reduced basicity compared to non-fluorinated pyridines.

Scientific Research Applications

• Synthesis of Various Compounds

  • Field : Organic Chemistry
  • Application : 5,6-difluoropyridine-3-carboxylic Acid can be used in the synthesis of various compounds.
  • Method : The specific methods of synthesis would depend on the target compound. Generally, it involves reactions with various reagents under controlled conditions.
  • Results : The outcome is the formation of various compounds, which can be used in further reactions or for various applications.

• Synthesis of Drugs

  • Field : Pharmaceutical Chemistry
  • Application : Fluorinated pyridines, like 5,6-difluoropyridine-3-carboxylic Acid, can be used in the synthesis of drugs.
  • Method : The methods of synthesis would depend on the specific drug being synthesized. It generally involves reactions with various reagents under controlled conditions.
  • Results : The outcome is the formation of drug molecules, which can be used for therapeutic purposes.

• Synthesis of Materials

  • Field : Material Science
  • Application : 5,6-difluoropyridine-3-carboxylic Acid can be used in the synthesis of various materials.
  • Method : The specific methods of synthesis would depend on the target material. It generally involves reactions with various reagents under controlled conditions.
  • Results : The outcome is the formation of various materials, which can be used for various applications.

• Synthesis of Fluorinated Pyridines

  • Field : Organic Chemistry
  • Application : 5,6-difluoropyridine-3-carboxylic Acid can be used in the synthesis of fluorinated pyridines.
  • Method : The specific methods of synthesis would depend on the target compound. Generally, it involves reactions with various reagents under controlled conditions.
  • Results : The outcome is the formation of fluorinated pyridines, which can be used in further reactions or for various applications.

• Nanotechnology and Polymers

  • Field : Nanotechnology
  • Application : Carboxylic acids like 5,6-difluoropyridine-3-carboxylic Acid can be used in nanotechnology and polymers.
  • Method : The methods of application would depend on the specific area of nanotechnology or polymer science. It generally involves reactions with various reagents under controlled conditions.
  • Results : The outcome is the formation of various nanomaterials or polymers, which can be used for various applications.

• Preparation of Poly (pyridine ether)s

  • Field : Polymer Chemistry
  • Application : 2,6-Difluoropyridine, a similar compound to 5,6-difluoropyridine-3-carboxylic Acid, has been used in the preparation of poly (pyridine ether)s.
  • Method : The method involves polycondensation with silylated 1,1,1- tris (4-hydroxyphenyl)ethane.
  • Results : The outcome is the formation of poly (pyridine ether)s.

• Synthesis of F 18 Substituted Pyridines

  • Field : Radiotherapy and Cancer Research
  • Application : Methods for synthesis of F 18 substituted pyridines for local radiotherapy of cancer and other biological active compounds are also presented.
  • Method : The specific methods of synthesis would depend on the target compound. Generally, it involves reactions with various reagents under controlled conditions.
  • Results : The outcome is the formation of F 18 substituted pyridines, which present a special interest as potential imaging agents for various biological applications.

• Modification of Nanoparticles and Nanostructures

  • Field : Nanotechnology
  • Application : Carboxylic acids like 5,6-difluoropyridine-3-carboxylic Acid can be used as surface modifiers to promote the dispersion and incorporation of metallic nanoparticles or carbon nanostructures.
  • Method : The methods of application would depend on the specific area of nanotechnology. It generally involves reactions with various reagents under controlled conditions.
  • Results : The outcome is the modification of the surface of nanoparticles and nanostructures, which can be used for various applications.

• Catalytic and Non-catalytic Amidation

  • Field : Organic Chemistry
  • Application : Carboxylic acids can be used in catalytic and non-catalytic amidation.
  • Method : The methods of application would depend on the specific reaction. It generally involves reactions with various reagents under controlled conditions.
  • Results : The outcome is the formation of amide bonds in good to excellent yields.

Safety And Hazards

Like many chemical compounds, fluoropyridines can pose certain hazards. They may cause skin and eye irritation, and may be harmful if inhaled or swallowed.

Future Directions

Fluoropyridines have potential applications in various fields, including medicine and agriculture. They are of interest in the development of new pharmaceuticals and agrochemicals.

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