85342-62-7 | N-Hydroxynaphthalimide triflate

CAS:85342-62-7 | N-Hydroxynaphthalimide triflate,Description

This compound is related to the field of isoquinoline derivatives, which are significant due to their diverse chemical reactions and properties. Research in this area often explores the synthesis of complex molecules that can serve as intermediates for further chemical transformations or as target molecules with potential applications in various domains.

Synthesis Analysis

The synthesis of isoquinoline derivatives, including compounds similar to 1,3-Dioxo-1h-benzo[de]isoquinolin-2(3h)-yl trifluoromethanesulfonate, has been explored through various catalytic methods. For instance, Rh(III)-catalyzed defluorinative annulation processes have been developed for the synthesis of 1,3,4-functionalized isoquinolines, utilizing 2-diazo-3,3,3-trifluoropropanoate as a nontraditional two-carbon reaction partner, indicating the versatility of synthesis approaches in this domain (Hao-Xiang Li et al., 2022).

Molecular Structure Analysis

The molecular structure of isoquinoline derivatives has been elucidated through various spectroscopic and X-ray diffraction methods. For example, studies on bis[μ-bis(diphenylphosphanyl)methane-κ2 P:P′]bis[(isoquinoline-κN)silver(I)] bis(trifluoromethanesulfonate)–isoquinoline complexes have provided insights into the coordination chemistry and structural features of isoquinoline compounds, revealing complex dinuclear structures (Xu Huang et al., 2012) .

Chemical Reactions and Properties

Isoquinoline derivatives undergo a variety of chemical reactions, including cycloaddition, annulation, and cyclization, leading to a wide range of functionalized molecules. The versatility in chemical reactions is highlighted by studies on visible-light-induced trifluoromethylation and difluoromethylation of N-benzamides with fluorinated sulfones, demonstrating the potential for creating CF2H/CF3-containing isoquinoline-1,3(2H,4H)-diones (G. Zou & Xuelin Wang, 2017).

Physical Properties Analysis

The physical properties of isoquinoline derivatives, including solubility, melting points, and crystal structure, are critical for their practical applications. Research in this area often focuses on the solid-state characterization to understand the material properties better, which can influence their handling and reactivity in further chemical processes.

Chemical Properties Analysis

The chemical properties of isoquinoline derivatives are influenced by their molecular structure, functional groups, and substituents. Studies on the reactivity, stability, and interactions with other molecules provide valuable information for designing new compounds with desired properties and activities. For instance, the exploration of ionic liquid-catalyzed syntheses showcases the impact of catalytic systems on the efficiency and selectivity of chemical transformations (Narjes Basirat et al., 2020).

Scientific Research Applications

• Agricultural Applications : N-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-amide derivatives have been found to effectively promote wheat and cucumber seed germination and exhibit high fungicidal activity. These compounds can be synthesized with high yield, indicating potential use in agricultural practices (Ju et al., 2016).
• Synthetic Chemistry : The compound facilitates versatile intramolecular Friedel-Crafts reactions, useful in synthesizing 3,4-dihydroisoquinolin-1(2H)-one derivatives and several isoquinoline derivatives (Murashige et al., 2015).
• Pharmacology and Biochemistry : Derivatives of this compound have been found to have promising antitumor activities and exhibit fluorescence, suggesting potential applications in cancer therapy (Xiao et al., 2019). Additionally, 1,8-naphthalimide derivatives with non-protein amino acids show cytotoxic activity against human tumor cell lines, indicating potential as a new anti-cancer agent (Marinov et al., 2019).
• Material Science : The compound has been utilized in the synthesis of organotin carboxylates, showing potential for organic synthesis and pharmacological applications (Xiao et al., 2013).
• Molecular Biology : Fluorescently labeled oligodeoxyribonucleotides, which can be synthesized using derivatives of this compound, show promise for biophysical studies and purification, due to their appreciable fluorescence and higher thermal denaturation values (Singh et al., 2007).

Future Directions

The future directions for this compound are not clear from the available information.

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