85686-97-1 | 1,2-difluoro-4,5-dinitrobenzene

CAS:85686-97-1 | 1,2-difluoro-4,5-dinitrobenzene,Description

1,2-Difluoro-4,5-dinitrobenzene, commonly referred to as DFDNB, is a highly versatile compound that has been used in a variety of scientific and industrial applications. It is a colorless, odorless, crystalline solid that is soluble in many organic solvents and is relatively stable under normal conditions. DFDNB is a strong oxidizing agent and has been used as a reagent in organic synthesis and as a catalyst in the production of polymers. It has also been used in the production of pharmaceuticals, dyes, and in the synthesis of a variety of other compounds. In addition, DFDNB has been studied for its potential use in the treatment of cancer, neurological disorders, and other diseases.
 

Scientific Research Applications

1. Determination of D-amino acids

• Application Summary : 1,5-difluoro-2,4-dinitrobenzene has been used as a bifunctional reagent for the determination of D-amino acids.
• Methods of Application : This compound contains a reactive fluorine atom which can be used for the reaction with a mixture of L- and D-amino acids. The resulting diastereomers can be separated and estimated by High Performance Liquid Chromatography (HPLC).
• Results : When artificial mixtures of the five amino acids containing known proportions of L- and D-isomers were derivatized with the reagent and the reaction products analyzed by HPLC, it was possible to determine the relative content of each isomer in nanomole range.

2. Cross-linking and Conjugation

• Application Summary : Difluorobenzene reagents, such as DFDNB, have been used for cross-linking phospholipids in human erythrocyte membranes, conjugation of small peptides to a carrier protein, studying protein interactions in the myelin membrane, cross-linking cytochrome oxidase subunits, and studying conformational effects of calcium on troponin C.
• Methods of Application : The specific methods of application or experimental procedures are not detailed in the source.
• Results : The specific results or outcomes obtained are not detailed in the source.

3. Contact-Sensitizing Hapten

• Application Summary : 1-Fluoro-2,4-dinitrobenzene is a contact-sensitizing hapten, commonly used in experimental studies on contact hypersensitivity, inducing itch model, and atopic dermatitis.
• Methods of Application : The specific methods of application or experimental procedures are not detailed in the source.
• Results : The specific results or outcomes obtained are not detailed in the source.

4. Oleanolic Acid NO-Releasing Derivative

• Application Summary : 1,5-Difluoro-2,4-dinitrobenzene acts as an oleanolic acid NO-releasing derivative used towards the treatment of colon cancer.
• Methods of Application : The specific methods of application or experimental procedures are not detailed in the source.
• Results : The specific results or outcomes obtained are not detailed in the source.

5. Synthesis of Beta Blockers

• Application Summary : 1,5-Difluoro-2,4-dinitrobenzene is also used in the synthesis of beta blockers used as bronchodilators.
• Methods of Application : The specific methods of application or experimental procedures are not detailed in the source.
• Results : The specific results or outcomes obtained are not detailed in the source.

6. Hematology Stains

• Application Summary : 1,2-Dichloro-4,5-dinitrobenzene is used in hematology for staining purposes.
• Methods of Application : The specific methods of application or experimental procedures are not detailed in the source.
• Results : The specific results or outcomes obtained are not detailed in the source.

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