868241-48-9 | 2,2-Difluoropropylamine hydrochloride

CAS:868241-48-9 | 2,2-Difluoropropylamine hydrochloride ,Description

2,2-Difluoropropylamine hydrochloride (DFPH) is an organic compound belonging to the class of amines. It is a colorless solid that is soluble in organic solvents and water. DFPH has been used in a variety of applications due to its unique properties. It is a versatile reagent that has been used in the synthesis of a variety of compounds, including pharmaceuticals, polymers, and other materials. Additionally, DFPH has been used in scientific research applications, such as in the study of enzyme inhibition and the development of new drug molecules. 
 

Scientific Research Applications

Fluorination in Organic Synthesis

Fluorine atoms and fluorinated moieties play pivotal roles in life science and materials science due to their unique properties. The introduction of difluoromethyl and monofluoromethyl groups into organic molecules often brings about beneficial effects, leading to the development of various pharmaceuticals and agrochemicals. Selective difluoromethylation and monofluoromethylation methods, which involve the introduction of CF2H and CH2F groups into organic molecules, represent straightforward synthetic approaches widely utilized in the design of CF2H- and CH2F-containing compounds (Jinbo Hu, Wei Zhang, & Fei Wang, 2009).

Passivation in Perovskite Solar Cells

The integration of fluoroethylamine (FEA) into perovskite films for defect passivation demonstrates the importance of fluorine-containing compounds in enhancing the efficiency and stability of perovskite solar cells. The distribution of fluorine atoms within the perovskite film plays a critical role in suppressing nonradiative recombination and improving carrier lifetime, contributing to the development of high-efficiency solar cells with enhanced environmental stability (Hang Su et al., 2021).

Novel Fluorinated Compounds for Tumor Hypoxia Detection

Fluorinated hypoxia-targeted compounds, including derivatives of 2,2-difluoropropylamine, have shown promise as non-invasive probes for measuring tumor hypoxia through 19F-magnetic resonance spectroscopy (19F-MRS). These compounds, capable of binding to hypoxic cells within tumors, offer a new avenue for the non-invasive detection of tumor hypoxia, which is crucial for understanding tumor biology and improving therapeutic strategies (M. Papadopoulou, M. Ji, & W. Bloomer, 2006).

Corrosion Inhibition

The study of the corrosion behavior of metals, particularly nickel alloys in hydrofluoric acid, underscores the significance of understanding how fluorine-containing compounds interact with materials. Such research is fundamental in industries where hydrofluoric acid is utilized, providing insights into material selection and corrosion prevention strategies (R. Rebak et al., 2001).

Synthesis of Fluorinated Compounds

The synthesis of fluorinated compounds, such as 3,3-difluoropyrrolidine hydrochloride from 2-chloro-2,2-difluoroacetic acid, highlights the diverse applications of fluorine chemistry in creating biologically active compounds. This area of research is crucial for the development of new pharmaceuticals and materials with enhanced properties (Lulin Wei et al., 2012).

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