870062-76-3 | 2-Chloro-3-fluoro-5-hydroxypyridine

CAS:870062-76-3 | 2-Chloro-3-fluoro-5-hydroxypyridine,Description

2-Chloro-3-fluoro-5-hydroxypyridine is an organic compound with the molecular formula C5H3ClFNO. It has a molecular weight of 147.54. The compound is solid in its physical form.

Molecular Structure Analysis

The InChI code for 2-Chloro-3-fluoro-5-hydroxypyridine is 1S/C5H3ClFNO/c6-5-4(7)1-3(9)2-8-5/h1-2,9H. This indicates the presence of chlorine, fluorine, and a hydroxyl group attached to a pyridine ring.

Physical And Chemical Properties Analysis

2-Chloro-3-fluoro-5-hydroxypyridine is a solid compound. It should be stored in an inert atmosphere at temperatures between 2-8°C.

Scientific Research Applications

• Synthesis of Fluorinated Pyridines

  • Field: Organic Chemistry
  • Application: Fluorinated pyridines, including 2-Chloro-3-fluoro-5-hydroxypyridine, are used in the synthesis of various organic compounds. They have interesting and unusual physical, chemical, and biological properties due to the presence of strong electron-withdrawing substituents in the aromatic ring.
  • Method: The methods of synthesis of 2-, 3-, 4-fluoropyridines, di-, tri-, polyfluoropyridines, perfluoroalkylpyridines, and also fluoropyridines fused with carbo-, heterocycles are presented.
  • Results: The introduction of fluorine atoms into lead structures has resulted in new agricultural products with improved physical, biological, and environmental properties.

• Synthesis of Benzo[4,5]furopyridine Tricyclic Heterocycles

  • Field: Organic Chemistry 
  • Application: 2-Chloro-3-hydroxypyridine, a related compound, has been used in the synthesis of all four possible benzo[4,5]furopyridine tricyclic heterocycles.
  • Method: The synthesis involves α and γ-activation of chloropyridines, as well as palladium-mediated reactions.
  • Results: This has resulted in the creation of benzo[4,5]furo[2,3-b]pyridine, benzo[4,5]furo[2,3-c]pyridine, benzo[4,5]furo[3,2-c]pyridine, and benzo[4,5]furo[3,2-b]pyridine.

• Preparation of Pyridine Derivatives as Thyroid Hormone β Receptor Agonists

  • Field: Medicinal Chemistry
  • Application: 3-Fluoro-5-hydroxypyridine, another related compound, is used in the preparation of pyridine derivatives as thyroid hormone β receptor agonists.
  • Method: The specific methods of application or experimental procedures are not detailed in the source.
  • Results: The outcomes of these preparations are not detailed in the source.

• Synthesis of Fluorinated Pyridines

  • Field: Organic Chemistry
  • Application: Fluorinated pyridines, including 2-Chloro-3-fluoro-5-hydroxypyridine, are used in the synthesis of various organic compounds. They have interesting and unusual physical, chemical, and biological properties due to the presence of strong electron-withdrawing substituents in the aromatic ring.
  • Method: The methods of synthesis of 2-, 3-, 4-fluoropyridines, di-, tri-, polyfluoropyridines, perfluoroalkylpyridines, and also fluoropyridines fused with carbo-, heterocycles are presented.
  • Results: The introduction of fluorine atoms into lead structures has resulted in new agricultural products with improved physical, biological, and environmental properties.

• Synthesis of Benzo[4,5]furopyridine Tricyclic Heterocycles

  • Field: Organic Chemistry 
  • Application: 2-Chloro-3-hydroxypyridine, a related compound, has been used in the synthesis of all four possible benzo[4,5]furopyridine tricyclic heterocycles.
  • Method: The synthesis involves α and γ-activation of chloropyridines, as well as palladium-mediated reactions.
  • Results: This has resulted in the creation of benzo[4,5]furo[2,3-b]pyridine, benzo[4,5]furo[2,3-c]pyridine, benzo[4,5]furo[3,2-c]pyridine, and benzo[4,5]furo[3,2-b]pyridine.

• Preparation of Pyridine Derivatives as Thyroid Hormone β Receptor Agonists

  • Field: Medicinal Chemistry
  • Application: 3-Fluoro-5-hydroxypyridine, another related compound, is used in the preparation of pyridine derivatives as thyroid hormone β receptor agonists.
  • Method: The specific methods of application or experimental procedures are not detailed in the source.
  • Results: The outcomes of these preparations are not detailed in the source.

Safety And Hazards

The compound is associated with several hazard statements, including H302, H315, H319, H332, and H335. These indicate that the compound may be harmful if swallowed, may cause skin irritation, may cause serious eye irritation, may be harmful if inhaled, and may cause respiratory irritation.

Future Directions

While specific future directions for 2-Chloro-3-fluoro-5-hydroxypyridine are not mentioned in the search results, similar compounds, such as trifluoromethylpyridines, have found applications in the agrochemical and pharmaceutical industries. It is expected that many novel applications of such compounds will be discovered in the future.

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