871700-18-4 | 1-cyclopropyl-3-(2-fluoro-4-iodophenyl)urea

CAS:871700-18-4 | 1-cyclopropyl-3-(2-fluoro-4-iodophenyl)urea,Description

1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)urea is a chemical compound with the CAS Number: 871700-18-4. It has a molecular weight of 320.11and its molecular formula is C10H10FIN2O.

Molecular Structure Analysis

The molecular structure of 1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)urea consists of a cyclopropyl group attached to a urea group, which is further attached to a phenyl ring. The phenyl ring is substituted with a fluorine atom at the 2nd position and an iodine atom at the 4th position.

Physical And Chemical Properties Analysis

1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)urea is a solid at room temperature. It has a density of 1.8±0.1 g/cm3. The boiling point is 332.0±42.0 °C at 760 mmHg. The compound has a molar refractivity of 63.7±0.4 cm3. It has 3 hydrogen bond acceptors and 2 hydrogen bond donors.

Scientific Research Applications

Urease Inhibitors and Potential Drugs

Urease inhibitors have been identified as potential therapeutic agents for treating gastric and urinary tract infections caused by urease-producing bacteria like Helicobacter pylori and Proteus species. The development of such inhibitors, including various urea derivatives, aims to overcome the limitations of current treatments, which may have severe side effects. This area of research highlights the medical significance of compounds like 1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)urea in developing safer and more effective treatments (Kosikowska & Berlicki, 2011).

Biosensors for Urea Detection

In the context of biosensors, urea derivatives are crucial in detecting and quantifying urea concentration, which is vital for diagnosing various health conditions related to abnormal urea levels in the body. Such biosensors utilize enzyme urease as a bioreceptor element, indicating the significant role of urea derivatives in enhancing the accuracy and efficiency of these devices (Botewad et al., 2021).

Role in Proteostasis

Research on 4-phenylbutyric acid, a related compound, provides insight into the role of urea derivatives in maintaining proteostasis. This involves the regulation of protein folding, which is crucial for preventing diseases associated with protein misfolding. Such studies demonstrate the broader implications of urea derivatives in understanding cellular mechanisms and developing therapies for related disorders (Kolb et al., 2015).

Agricultural and Environmental Science

In agriculture, urea derivatives are explored for their potential to improve the efficiency of urea utilization in ruminants and as a hydrogen carrier for sustainable energy supply. These applications emphasize the environmental and agricultural benefits of urea derivatives, such as reducing nitrogen loss and contributing to cleaner energy solutions (Jin et al., 2018); (Rollinson et al., 2011).

Safety And Hazards

The compound is labeled with the signal word “Warning” and is associated with the hazard statements H302, H315, H319, H335. The precautionary statements associated with it are P261, P280, P301, P301, P302, P305, P312, P338, P351, P352.

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