87189-16-0 | Potassium 2-bromo-2,2-difluoroacetate

CAS:87189-16-0 | Potassium 2-bromo-2,2-difluoroacetate ,Description

Potassium 2-bromo-2,2-difluoroacetate (KBDFA) is an organic compound with a wide range of applications in scientific research. It is a colorless, odorless, crystalline solid that is soluble in water and a variety of organic solvents. KBDFA has been used in organic synthesis and in the preparation of other organic compounds. It is also used in the preparation of pharmaceuticals and in the synthesis of polymers. In addition, KBDFA has been studied for its potential to act as a catalyst in the production of polymers. 
 

Scientific Research Applications

Synthetic Methods and Chemical Reactions

• Synthesis of Functionalized Organotrifluoroborates: Potassium 2-bromo-2,2-difluoroacetate is utilized in the synthesis of organotrifluoroborates, involving in situ reactions and nucleophilic substitution processes (Molander & Ham, 2006).
• Reactions with Vinyl Ethers: This compound participates in radical reactions with vinyl ethers, used in methodologies for synthesizing difluoro or monofluoroacetyl-substituted acetals (Kondratov et al., 2015).
• Visible-Light-Driven Direct 2,2-Difluoroacetylation: It reacts under visible light with alkenes to achieve direct 2,2-difluoroacetylation, producing various difluoroalkanoates (Furukawa et al., 2020).
• Synthesis of Gem-Difluorinated Compounds: Potassium 2-bromo-2,2-difluoroacetate serves as a source of CF2-fragment in the synthesis of gem-difluorinated compounds from organozinc reagents (Levin et al., 2015).
• Formation of Difluoroallenes: It is involved in the preparation of 2-bromo-3,3-difluoroallylic acetates, which are then treated to form difluoroallenes (Yokota et al., 2009).
• Palladium-Catalyzed Cross-Coupling Reactions: This compound is used in Suzuki-Miyaura cross-coupling reactions, demonstrating the versatility of potassium 2-bromo-2,2-difluoroacetate in organic synthesis (Molander & Biolatto, 2003).
• photochemistry (Xiang et al., 2017).

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