872041-86-6 | 5-Fluoropyridin-3-ylboronic acid

CAS:872041-86-6 | 5-Fluoropyridin-3-ylboronic acid,Description

5-Fluoropyridine-3-boronic acid is a pharmaceutical intermediate. It is a product of Thermo Scientific Chemicals and was originally part of the Alfa Aesar product portfolio.

Molecular Structure Analysis

The molecular formula of 5-Fluoropyridine-3-boronic acid is C5H5BFNO2. The InChI Key is FVEDGBRHTGXPOK-UHFFFAOYSA-N.

Chemical Reactions Analysis

Boronic acids, such as 5-Fluoropyridine-3-boronic acid, are commonly used in Suzuki–Miyaura coupling reactions. This reaction is a type of palladium-catalyzed cross-coupling reaction, which is used to form carbon-carbon bonds.

Physical And Chemical Properties Analysis

5-Fluoropyridine-3-boronic acid appears as white to cream or pale yellow crystals or crystalline powder. It is soluble in hot methanol. The molecular weight is 140.91.

Scientific Research Applications

“5-Fluoropyridine-3-boronic acid” is primarily used as a pharmaceutical intermediate. This means it’s a substance produced during the synthesis of a pharmaceutical drug. It’s an important component in the production of various pharmaceuticals.

Another potential application of “5-Fluoropyridine-3-boronic acid” is in the Suzuki–Miyaura coupling. The Suzuki–Miyaura coupling is a type of chemical reaction where a carbon–carbon bond is formed from a boron compound and an organic halide in the presence of a palladium catalyst. This reaction is widely used in organic chemistry to create carbon–carbon bonds, which are crucial in the creation of complex organic molecules.

“5-Fluoropyridine-3-boronic acid” is primarily used as a pharmaceutical intermediate. This means it’s a substance produced during the synthesis of a pharmaceutical drug. It’s an important component in the production of various pharmaceuticals.

Another potential application of “5-Fluoropyridine-3-boronic acid” is in the Suzuki–Miyaura coupling. The Suzuki–Miyaura coupling is a type of chemical reaction where a carbon–carbon bond is formed from a boron compound and an organic halide in the presence of a palladium catalyst. This reaction is widely used in organic chemistry to create carbon–carbon bonds, which are crucial in the creation of complex organic molecules.

Boronic acids, including “5-Fluoropyridine-3-boronic acid”, are increasingly utilized in diverse areas of research. They interact with diols and strong Lewis bases such as fluoride or cyanide anions, leading to their utility in various sensing applications. These sensing applications can be homogeneous assays or heterogeneous detection. Boronic acids are also used for electrophoresis of glycated molecules, as building materials for microparticles for analytical methods, and in polymers for the controlled release of insulin.

Safety And Hazards

5-Fluoropyridine-3-boronic acid is considered hazardous. It can cause skin irritation, serious eye irritation, and may cause respiratory irritation. It is recommended to avoid breathing its dust/fume/gas/mist/vapors/spray and to use it only outdoors or in a well-ventilated area.

Future Directions

While specific future directions for 5-Fluoropyridine-3-boronic acid are not mentioned in the available resources, boronic acids have been well developed as sensors to recognize carbohydrates or other substances. This suggests potential future applications in the field of sensor development.

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