886510-21-0 | 3-FLUORO-2-TRIFLUOROMETHYLPYRIDINE

CAS:886510-21-0 | 3-FLUORO-2-TRIFLUOROMETHYLPYRIDINE,Description

3-Fluoro-2-(trifluoromethyl)pyridine is a fluorinated building block. It participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine.

Synthesis Analysis

The synthesis of 3-Fluoro-2-(trifluoromethyl)pyridine involves a Pd-catalyzed coupling reaction. It also participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine. More details about the synthesis process can be found in the relevant papers.

Molecular Structure Analysis

The molecular structure of 3-Fluoro-2-(trifluoromethyl)pyridine can be found in the relevant databases.

Chemical Reactions Analysis

3-Fluoro-2-(trifluoromethyl)pyridine is used as a reactant in the preparation of aminopyridines through amination reactions. More details about the chemical reactions can be found in the relevant papers.

Physical And Chemical Properties Analysis

3-Fluoro-2-(trifluoromethyl)pyridine has a molecular weight of 165.09, and its empirical formula is C6H3F4N. It is a liquid with a refractive index of 1.409 and a density of 1.384 g/mL at 25 °C.

Scientific Research Applications

• Agrochemical Industry

  • Trifluoromethylpyridines (TFMPs) and their derivatives are widely used in the agrochemical industry. The major use of TFMP derivatives is in the protection of crops from pests.
  • The synthesis of TFMP derivatives involves various methods, including the vapor-phase reaction.
  • More than 20 new TFMP-containing agrochemicals have acquired ISO common names.

• Pharmaceutical Industry

  • Several TFMP derivatives are also used in the pharmaceutical industry.
  • Five pharmaceutical products containing the TFMP moiety have been granted market approval, and many candidates are currently undergoing clinical trials.
  • The biological activities of TFMP derivatives are thought to be due to the combination of the unique physicochemical properties of the fluorine atom and the unique characteristics of the pyridine moiety.

• Synthesis of Metal-Organic Frameworks (MOFs)

  • TFMPs can be used in the synthesis of metal-organic frameworks (MOFs).

• Synthesis of Methiodide Salts

  • TFMPs can be used in the synthesis of methiodide salts.

• Preparation of Aminopyridines

  • 2-Fluoro-4-(trifluoromethyl)pyridine, a type of TFMP, can act as a reactant in the preparation of aminopyridines through amination reactions.

• Catalytic Ligand for Regioselective Preparation of Tetramethylbiphenyls

  • 2-Fluoro-4-(trifluoromethyl)pyridine can be used as a catalytic ligand for regioselective preparation of tetramethylbiphenyls through aerobic oxidative coupling of xylene catalyzed by palladium.

• Preparation of (trifluoromethyl)pyridyllithiums

  • 3-Fluoro-2-(trifluoromethyl)pyridine can be used in the preparation of (trifluoromethyl)pyridyllithiums via metalation reaction. The specific methods of application or experimental procedures for this use are not detailed in the available sources.

• Synthesis of Fluorinated Organic Chemicals

  • Many recent advances in the agrochemical, pharmaceutical, and functional materials fields have been made possible by the development of organic compounds containing fluorine. The effects of fluorine and fluorine-containing moieties on the biological activities and physical properties of compounds have earned fluorine a unique place in the arsenal of the discovery chemist.

• Animal Health Products

  • Several trifluoromethylpyridine derivatives are also used in the veterinary industries. Two veterinary products containing the trifluoromethylpyridine moiety have been granted market approval, and many candidates are currently undergoing clinical trials.

• Preparation of (trifluoromethyl)pyridyllithiums

  • 3-Fluoro-2-(trifluoromethyl)pyridine can be used in the preparation of (trifluoromethyl)pyridyllithiums via metalation reaction. The specific methods of application or experimental procedures for this use are not detailed in the available sources.

• Synthesis of Fluorinated Organic Chemicals

  • Many recent advances in the agrochemical, pharmaceutical, and functional materials fields have been made possible by the development of organic compounds containing fluorine. The effects of fluorine and fluorine-containing moieties on the biological activities and physical properties of compounds have earned fluorine a unique place in the arsenal of the discovery chemist. As the number of applications for these compounds continues to grow, the development of fluorinated organic chemicals is becoming an increasingly important research topic.

• Animal Health Products

  • Several trifluoromethylpyridine derivatives are also used in the veterinary industries. Two veterinary products containing the trifluoromethylpyridine moiety have been granted market approval, and many candidates are currently undergoing clinical trials.

Safety And Hazards

This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard. It has acute oral toxicity, acute dermal toxicity, and acute inhalation toxicity. It can cause skin corrosion/irritation and serious eye damage/eye irritation. It can also cause specific target organ toxicity (single exposure), with the respiratory system being the target organ.

Future Directions

Trifluoromethylpyridine (TFMP) and its derivatives, including 3-Fluoro-2-(trifluoromethyl)pyridine, have gained a fundamental role as key structural ingredients for the development of many agrochemical and pharmaceutical compounds. It is expected that many novel applications of TFMP will be discovered in the future.

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