887583-90-6 | 4-Bromo-2-(trifluoromethyl)pyridine

CAS:887583-90-6 | 4-Bromo-2-(trifluoromethyl)pyridine ,Description

4-Bromo-2-(trifluoromethyl)pyridine is an organic compound with the molecular formula C5H3BrF3N. It is a colorless liquid with a pungent odor and is soluble in water. It has been used in various scientific research applications, including organic synthesis, medicinal chemistry, and materials science. 
 

Scientific Research Applications

1. Spectroscopic and Antimicrobial Studies

4-Bromo-2-(trifluoromethyl)pyridine and its derivatives have been the subject of spectroscopic studies, such as Fourier Transform-Infrared (FT-IR) and Nuclear Magnetic Resonance (NMR) spectroscopies. These studies also extend to examining their antimicrobial activities, with some compounds showing potential in this area (Vural & Kara, 2017).

2. Synthesis of Novel Pyridine Derivatives

The compound serves as a starting point for synthesizing novel pyridine derivatives. For example, it has been used in palladium-catalyzed Suzuki cross-coupling reactions to create new compounds with potential biological activities (Ahmad et al., 2017).

3. Building Blocks in Metalloorganic Structures

Derivatives of 4-Bromo-2-(trifluoromethyl)pyridine are valuable as building blocks in complexation and metalloorganic structures. These structures are useful for tuning chelating and photophysical properties, indicating their potential in materials science and coordination chemistry (Ruiz-Crespo et al., 2022).

4. Intermediate in Synthesis of Biologically Active Compounds

This compound is also an important intermediate in the synthesis of various biologically active compounds, highlighting its significance in pharmaceutical research and development (Wang et al., 2016).

5. Preparation of Trifluoromethyl-Substituted Compounds

It has been used as a building block for the preparation of trifluoromethyl-substituted compounds, which are significant in developing pharmaceuticals and agrochemicals (Khlebnikov et al., 2018).

6. Direct Synthesis of Fluorinated Azaheterocycles

The compound plays a role in the synthesis of fluorinated azaheterocycles, which are important in medicinal chemistry due to their biological significance (Usachev et al., 2021).

7. Deprotonative Functionalization in Organic Synthesis

It has been involved in the deprotonative functionalization of pyridine derivatives, showcasing its versatility in organic synthesis (Shigeno et al., 2019).

8. Chemoselective Sonogashira Cross-Coupling Reactions

The compound is a substrate in chemoselective Sonogashira reactions, which are pivotal in synthesizing alkynylated pyridines used in various applications including fluorescence studies (Rivera et al., 2019).

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