887584-91-0 | 3,4-Difluoro-5-hydroxybenzaldehyde

CAS:887584-91-0 | 3,4-Difluoro-5-hydroxybenzaldehyde,Description

3,4-Difluoro-5-hydroxybenzaldehyde is an organic compound with the molecular formula C7H4F2O2 and a molecular weight of 158.1. It is a solid substance that is stored in an inert atmosphere at temperatures between 2-8°C.

Molecular Structure Analysis

The InChI code for 3,4-Difluoro-5-hydroxybenzaldehyde is 1S/C7H4F2O2/c8-5-1-4 (3-10)2-6 (11)7 (5)9/h1-3,11H. This indicates that the compound has a benzene ring with two fluorine atoms and one hydroxyl group attached to it.

Physical And Chemical Properties Analysis

3,4-Difluoro-5-hydroxybenzaldehyde is a solid substance. It is stored in an inert atmosphere at temperatures between 2-8°C.

Scientific Research Applications

Synthesis and Applications in Anticancer Research

3,4-Difluoro-5-hydroxybenzaldehyde has been explored for its potential in the synthesis of fluorinated analogues of combretastatin A-4, a compound known for its anticancer properties. The study by Lawrence et al. (2003) describes the Wittig synthesis of fluoro-substituted stilbenes using fluorinated benzaldehydes, including 3,5-Difluoro-4-hydroxybenzaldehyde, to create analogues of combretastatin. These fluorinated compounds retain the cell growth inhibitory properties of combretastatin A-4, indicating the potential therapeutic applications of 3,4-Difluoro-5-hydroxybenzaldehyde in anticancer drug synthesis (Lawrence et al., 2003).

Contributions to Organic Synthesis and Chemical Research

Further research into the synthesis and properties of compounds related to 3,4-Difluoro-5-hydroxybenzaldehyde can be seen in studies involving the synthesis of various benzaldehyde derivatives. For example, the synthesis of 3,4,5-Trimethoxybenzaldehyde from p-cresol demonstrates the versatility and importance of benzaldehyde derivatives in organic synthesis, potentially including those related to 3,4-Difluoro-5-hydroxybenzaldehyde (Ya, 2001). Additionally, the synthesis and characterization of novel isocyanide-based reactions for producing 3,4-dihydrocoumarin derivatives highlight the role of hydroxybenzaldehydes in facilitating multifaceted organic synthesis processes (Shaabani et al., 2008).

In-depth Chemical Studies and Structural Analysis

Safety And Hazards

The compound is labeled with the GHS07 pictogram, indicating that it can cause certain health hazards. The hazard statements associated with the compound are H302, H315, H319, and H335, indicating that it can be harmful if swallowed, can cause skin irritation, can cause serious eye irritation, and may cause respiratory irritation. The precautionary statements are P261, P305+P351+P338, advising to avoid breathing dust/fume/gas/mist/vapors/spray, and if in eyes, rinse cautiously with water for several minutes.

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