915720-64-8 | 5-fluoro-6-Methyl-2-Pyridinecarbonitrile

CAS:915720-64-8 | 5-fluoro-6-Methyl-2-Pyridinecarbonitrile,Description

5-Fluoro-6-methylpicolinonitrile is a chemical compound with the CAS Number: 915720-64-8 and a molecular weight of 136.13. It has a linear formula of C7H5FN2. It is a solid substance stored in an inert atmosphere at room temperature.

Scientific Research Applications

Radiopharmaceutical Development

• PET Imaging of Neurofibrillary Tangles : A study reported the synthesis of [18 F]MK-6240, a radiopharmaceutical for PET imaging of neurofibrillary tangles in the human brain, using a precursor related to 5-Fluoro-6-methylpicolinonitrile. This compound demonstrates potential for detecting tau protein aggregations, crucial for Alzheimer's disease diagnosis and research (Collier et al., 2017).

Synthetic Chemistry and Methodology

• Cascade Cyclization for Herbicide Synthesis : Research into the cascade cyclization of fluoroalkyl alkynylimines, involving structures related to 5-Fluoro-6-methylpicolinonitrile, led to the development of novel fluoropicolinate herbicides. This method facilitated the synthesis of compounds previously inaccessible, highlighting the role of fluoroalkyl compounds in agricultural chemistry advancements (Johnson et al., 2015).

Fundamental Research in Fluorine Chemistry

• Mechanism of Enzymatic Fluorination : The mechanism of enzymatic fluorination in Streptomyces cattleya, which involves the synthesis of 5'-fluoro-5'-deoxy adenosine from S-adenosyl-l-methionine and fluoride ion, was elucidated. This research provides insights into the biosynthesis of fluorinated metabolites, contributing to our understanding of the role and reactivity of organofluorine compounds in nature (Zhu et al., 2007).

Safety And Hazards

The safety information available indicates that 5-Fluoro-6-methylpicolinonitrile is associated with some hazards. The pictograms indicate a GHS07 signal word warning. The hazard statements include H302-H312-H332, and the precautionary statements include P280.

Future Directions

Fluorinated compounds, such as 5-Fluoro-6-methylpicolinonitrile, are gaining increasing attention from researchers due to their unique properties and potential applications. They are widely used in various fields such as molecular imaging, pharmaceuticals, and materials. The introduction of fluorine atoms into organic compound molecules can give these compounds new functions and improve their performance. Therefore, the future research and development of fluorinated compounds like 5-Fluoro-6-methylpicolinonitrile are promising.

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