924305-06-6 | 4-FLUORO-ISOINDOLINE HCL

CAS:924305-06-6 | 4-FLUORO-ISOINDOLINE HCL,Description

4-Fluoroisoindoline Hydrochloride (FIH) is an organic compound that belongs to the class of heterocycles. It is also known as 4-Fluoro-1H-isoindoline hydrochloride. The empirical formula is C8H8FN · HCland the molecular weight is 173.62 g/mol.

Molecular Structure Analysis

The molecular formula of 4-Fluoroisoindoline Hydrochloride is C8H9ClFN. The average mass is 173.615 Da and the monoisotopic mass is 173.040756 Da.

Physical And Chemical Properties Analysis

4-Fluoroisoindoline Hydrochloride is a solid with a melting point of 191-196 °C. It should be stored at a temperature of 2-8°C. The SMILES string representation of the molecule is Cl.Fc1cccc2CNCc12.

Scientific Research Applications

Synthesis and Medicinal Chemistry

• Acetylcholinesterase Inhibitors :
  • A synthesis method involving 4-Fluoroisoindoline Hydrochloride led to the production of potent acetylcholinesterase inhibitors. These compounds are significant in the context of Alzheimer's disease and other neurodegenerative disorders where acetylcholinesterase's role is crucial (Basappa et al., 2004) .
  • Another study focused on a series of 1,2-benzisoxazole hydrochlorides, including those with a 4-Fluoroisoindoline structure, showed promising activity against acetylcholinesterase, suggesting potential applications in the treatment of neurodegenerative diseases (Rangappa & Basappa, 2005).

Biochemical Research

• Biological Activity Studies :
  • A synthesized compound containing 4-Fluoroisoindoline showed significant anti-tuberculosis activity, demonstrating its potential as a therapeutic agent against tuberculosis. Additionally, this compound exhibited superior anti-microbial activity, highlighting its broad-spectrum potential in infectious disease treatment (Mamatha S.V et al., 2019).
  • In the study of derivatives of 4-fluoro-5-sulfonylisoquinoline, unique molecular conformations and interactions were observed, contributing to a deeper understanding of molecular structures and their applications in pharmaceuticals (Ohba et al., 2012).

Development of Antimalarial Agents

• Antimalarial Drug Development :
  • Research into 4'-fluoro analogues of amodiaquine, including those with 4-Fluoroisoindoline structures, has led to the identification of compounds with potent activity against malaria. This study highlights the role of 4-Fluoroisoindoline derivatives in developing new antimalarial drugs (O’Neill et al., 2009) .

Chemical Synthesis and Characterization

• Chemical Synthesis :
  • A diastereoselective synthesis of 4-Fluoro-threonine was reported, laying the groundwork for spectroscopic characterization and theoretical investigations. This kind of research is crucial for understanding the properties and potential applications of fluorinated amino acids (Potenti et al., 2021).
  • Modifications of the isoquinoline-1,3-dione scaffold, including the introduction of a fluorine atom, have been studied for their medicinal relevance, indicating the importance of 4-Fluoroisoindoline structures in developing novel pharmaceutical compounds (Golushko et al., 2019).

Safety And Hazards

4-Fluoroisoindoline Hydrochloride is classified as a skin irritant (Category 2), eye irritant (Category 2A), and specific target organ toxicity - single exposure (Category 3) affecting the respiratory system. It is recommended to avoid breathing dust, ensure adequate ventilation, and use personal protective equipment when handling this compound.

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