943-08-8 | 2-[(Difluoromethyl)sulfanyl]-1,3-benzothiazole

CAS:943-08-8 | 2-[(Difluoromethyl)sulfanyl]-1,3-benzothiazole ,Description

2-[(Difluoromethyl)sulfanyl]-1,3-benzothiazole (DFMBT) is an organic compound belonging to the class of heterocyclic compounds. It is a white crystalline solid with a molecular weight of 198.16 g/mol and a melting point of 161-163 °C. DFMBT is soluble in water, methanol, ethanol, and acetic acid. It is an important building block in organic synthesis and has a wide range of applications in medicinal chemistry, agrochemicals, and material science.
 

Scientific Research Applications

Antifungal Activity

A study by Łukowska-Chojnacka et al. (2016) highlights the synthesis of novel tetrazole derivatives incorporating benzothiazole moieties. These compounds showed significant antifungal activity against various moulds and yeasts, particularly Candida albicans, demonstrating high cell growth inhibition. This study indicates the potential use of 2-[(difluoromethyl)sulfanyl]-1,3-benzothiazole derivatives in developing new antifungal agents (Łukowska-Chojnacka et al., 2016) .

Antimicrobial Properties

Alsarahni et al. (2017) synthesized amino acetylenic and thiocarbonate derivatives of 2-mercaptobenzothiazole, demonstrating potent antimicrobial activity. These compounds, including variations of 2-[(difluoromethyl)sulfanyl]-1,3-benzothiazole, exhibited high efficacy against Pseudomonas aeruginosa and Candida albicans, suggesting their application in antimicrobial treatments (Alsarahni et al., 2017).

Synthesis of Benzothiazole Derivatives

The work of Feng-Yan Ge et al. (2007) focuses on the efficient one-pot synthesis of 2-trifluoromethyl and 2-difluoromethyl substituted benzothiazole derivatives. These derivatives can be utilized in the synthesis of new drugs, demonstrating the versatility of 2-[(difluoromethyl)sulfanyl]-1,3-benzothiazole in drug development (Feng-Yan Ge et al., 2007).

Anti-Inflammatory and Antibacterial Activities

A study by Mayura Kale and Deepak Mene (2013) explored the synthesis of fused imino pyrimido benzothiazole derivatives, including 2-[(difluoromethyl)sulfanyl]-1,3-benzothiazole. These compounds exhibited notable anti-inflammatory and antibacterial properties, suggesting their potential as therapeutic agents for related conditions (Mayura Kale and Deepak Mene, 2013).

Antidiabetic Evaluation

Vijayan et al. (2021) conducted a study on benzothiazole substituted oxadiazole derivatives, including 2-[(difluoromethyl)sulfanyl]-1,3-benzothiazole variants. Their research revealed significant anti-diabetic properties, highlighting the potential of these compounds in developing new diabetes treatments (Vijayan et al., 2021).

Antitumor Activity

Research by E. Ramadan et al. (2018) involved synthesizing 2-substituted sulfanyl benzo[d]thiazoles, including derivatives of 2-[(difluoromethyl)sulfanyl]-1,3-benzothiazole. These compounds showed promising antitumor activity, particularly against Ehrlich ascites carcinoma cells, indicating their potential application in cancer therapy (E. Ramadan et al., 2018).

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