96145-98-1 | 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol

CAS:96145-98-1 | 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol,Description

Synthesis Analysis

The synthesis of pyrazole derivatives, including compounds similar to 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol, often involves the reaction of aryl aldehydes with 1-phenyl-3-trifluoromethylpyrazol-5-one in aqueous media without a catalyst. This method has been noted for its environmental friendliness, high yields, and mild reaction conditions (Yao et al., 2007).

Molecular Structure Analysis

Pyrazole derivatives exhibit a wide range of molecular structures, depending on the substituents attached to the pyrazole ring. X-ray crystallography studies have revealed that these compounds can crystallize in various systems, displaying interesting structural features. For instance, the crystal and molecular structure of a related compound showed an almost planar conformation stabilized by intramolecular interactions (Mojzych et al., 2005).

Chemical Reactions and Properties

Pyrazole derivatives are known for their reactivity towards a variety of chemical reactions. Anionic triflyldiazomethane species, for example, have been utilized for the synthesis of pyrazole triflones containing a triflyl group, demonstrating the versatility of pyrazole compounds in synthetic chemistry (Das et al., 2018).

Scientific Research Applications

• Agrochemical and Pharmaceutical Industries 
  • Summary of Application : 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol is a key structural motif in active agrochemical and pharmaceutical ingredients. Its derivatives are used in the protection of crops from pests. More than 20 new trifluoromethylpyridine (TFMP)-containing agrochemicals have acquired ISO common names. Several TFMP derivatives are also used in the pharmaceutical and veterinary industries.
  • Methods of Application : The major use of TFMP derivatives is in the protection of crops from pests. For example, Fluazifop-butyl was the first TFMP derivative introduced to the agrochemical market. In the pharmaceutical industry, five pharmaceutical and two veterinary products containing the TFMP moiety have been granted market approval.
  • Results or Outcomes : The biological activities of TFMP derivatives are thought to be due to the combination of the unique physicochemical properties of the fluorine atom and the unique characteristics of the pyridine moiety. Many candidates are currently undergoing clinical trials.
• Synthesis of Other Compounds 
  • Summary of Application : 5-Hydroxy-1-phenyl-3-trifluoromethylpyrazole, a derivative of 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol, is used in the preparation of 5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, an inhibitor of ADAMTS-5.
  • Methods of Application : The specific methods of synthesis were not provided in the source.
  • Results or Outcomes : The specific results or outcomes were not provided in the source.

Safety And Hazards

The compound is classified as a warning under the GHS classification. It has hazard statements H315-H319-H335, indicating it can cause skin irritation, serious eye irritation, and may cause respiratory irritation. Precautionary measures include avoiding breathing dust/fume/gas/mist/vapors/spray and washing thoroughly after handling.

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